Proceedings ArticleDOI
Dual unit visual intraocular prosthesis
Wentai Liu,E. McGucken,K. Vitchiechom,M. Clements,E. de Juan,Mark S. Humayun +5 more
- Vol. 5, pp 2303-2306
TLDR
The development of an implantable Artificial Retina Chipset (ARC) is presented, and the authors' current design, comprised of the Dual Unit Visual Intraocular Prosthesis, is described.Abstract:
The development of an implantable Artificial Retina Chipset (ARC) is presented, and the authors' current design, comprised of the Dual Unit Visual Intraocular Prosthesis, is described. This device will enable the over 10,000,000 people afflicted by retinal diseases such as retinal pigmentosa (RP) and age-related macular degeneration (AMD) to regain the sense of sight. This technology takes advantage of the fact that although these retinal diseases render the rods and cones inoperative, the ganglion cells lining the retina remain intact, and can respond to electrical stimulation. The ARC consists of a photosensing, processing, and stimulus-driving chip powered by solar cells which is connected to an electrode array. A photosensing, processing, and stimulus-driving chip has been fabricated and tested, and the chip performs in accordance with design specifications and biological parameters. The chip is capable of delivering the requisite currents for retinal stimulation in humans, as were determined by clinical studies conducted on the visually impaired with RP and AMD.read more
Citations
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Journal ArticleDOI
Retinal Prosthesis for the Blind
Eyal Margalit,Mauricio Maia,James D. Weiland,Robert J. Greenberg,Gildo Y. Fujii,Gustavo Torres,Duke V. Piyathaisere,Thomas M. O’Hearn,Wentai Liu,Gianluca Lazzi,Gislin Dagnelie,Dean A. Scribner,Eugene de Juan,Mark S. Humayun +13 more
TL;DR: Cortical prostheses will be described only because of their direct effect on the concept and technical development of the other prostheses, and this will be done in a more general and historic perspective.
Journal ArticleDOI
A neuro-stimulus chip with telemetry unit for retinal prosthetic device
Wentai Liu,K. Vichienchom,M. Clements,S.C. DeMarco,C. Hughes,E. McGucken,Mark S. Humayun,E. de Juan,James D. Weiland,Robert J. Greenberg +9 more
TL;DR: A microchip which serves as the telemetry protocol decoder and stimulus signal generator is fabricated by MOSIS with 1.2-mm CMOS technology and was demonstrated to provide the desired biphasic current stimulus pulses for an array of 100 retinal electrodes at video frame rates.
Journal Article
Long-term histological and electrophysiological results of an inactive epiretinal electrode array implantation in dogs.
Ajit B. Majji,Mark S. Humayun,James D. Weiland,Satoshi Suzuki,Salvatore A. D'Anna,Eugene de Juan +5 more
TL;DR: With the success of implanting an electrically inactive device onto the retinal surface for prolonged periods, the effects of long-term retinal electrical stimulation are now ready to be tested as the next step toward developing a prototype retinal prosthesis for human use.
Journal ArticleDOI
Intraocular retinal prosthesis
James D. Weiland,Mark S. Humayun +1 more
TL;DR: In this paper, the epiretinal implant was used to restore some level of visual function to blind individuals. But, the retinal response to stimulation was not investigated. And, it was not shown that the implant still allowed test subjects to perform simple visual tasks.
Journal ArticleDOI
Electronic retinal implants and artificial vision: Journey and present
TL;DR: Two retinal implants appear the most likely to succeed in the future having undergone multicentre human trials: the Argus II electronic epiretinal device (Second Sight Medical Products, CA, USA) and Alpha-IMS electronic subretinal devices (Retina Implant AG, Germany).
References
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Book
Analog VLSI and Neural Systems
TL;DR: This chapter discusses a simple circuit that can generate a sinusoidal response and calls this circuit the second-order section, which can be used to generate any response that can be represented by two poles in the complex plane, where the two poles have both real and imaginary parts.
Journal ArticleDOI
Visual perception elicited by electrical stimulation of retina in blind humans.
Mark S. Humayun,Eugene de Juan,Gislin Dagnelie,Robert J. Greenberg,Roy H. Propst,D. Howard Phillips +5 more
TL;DR: Evaluating the feasibility of bypassing damaged photoreceptors and electrically stimulating the remaining viable retinal layers to provide limited visual input to patients who are blind because of severe photoreceptor degeneration results in focal light perception that seems to arise from the stimulated area.
Patent
Artificial retina device
Alan Y. Chow,Vincent Y. Chow +1 more
TL;DR: In this article, a silicon chip device composed of a large array of densely packed microphotodiodes is implanted between the inner and outer retina layers, in patients with vision-deficient eyes suffering from retinal dysfunction, to allow for useful formed vision.
Journal ArticleDOI
Retinal excitation and inhibition from direct electrical stimulation.
D. R. Crapper,W. K. Noell +1 more
Journal Article
The electrical stimulation of the retina by indwelling electrodes.
William W. Dawson,N D Radtke +1 more
TL;DR: Retinal excitability also decreased when electrical stimuli were delivered more often than one per 5 seconds, and effective charge-density threshold was moderately greater than reported for frogs and humans.