Journal ArticleDOI
Dynamics of magnetic particles in cylindrical Halbach array: implications for magnetic cell separation and drug targeting
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TLDR
Analyzing snapshots of trajectories of hundred magnetite particles of each size in the water as well as in the air, it is found that optimally designed magnetic circuits of permanent magnets in quadrupolar Halbach array have substantially shorter capture time than simple blocks of permanent magnet commonly used in experiments.Abstract:
Magnetic nanoparticles for therapy and diagnosis are at the leading edge of the rapidly developing field of bionanotechnology In this study, we have theoretically studied motion of magnetic nano- as well as micro-particles in the field of cylindrical Halbach array of permanent magnets Magnetic flux density was modeled as magnetostatic problem by finite element method and particle motion was described using system of ordinary differential equations—Newton law Computations were done for nanoparticles Nanomag®-D with radius 65 nm, which are often used in magnetic drug targeting, as well as microparticles DynaBeads-M280 with radius 14 µm, which can be used for magnetic separation Analyzing snapshots of trajectories of hundred magnetite particles of each size in the water as well as in the air, we have found that optimally designed magnetic circuits of permanent magnets in quadrupolar Halbach array have substantially shorter capture time than simple blocks of permanent magnets commonly used in experiments, therefore, such a Halbach array may be useful as a potential source of magnetic field for magnetic separation and targeting of magnetic nanoparticles as well as microparticles for delivery of drugs, genes, and cells in various biomedical applicationsread more
Citations
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Journal ArticleDOI
Particle Transport in Therapeutic Magnetic Fields
Ishwar K. Puri,Ranjan Ganguly +1 more
TL;DR: This review explains the behavior of magnetic nano- and microparticles during magnetic drug targeting and magnetic fluid hyperthermia, and the microfluidic transport of these particles in bioMEMS (biomedical microelectromechanical systems) devices for ex vivo therapeutic and diagnostic applications.
Journal ArticleDOI
Permanent magnet system to guide superparamagnetic particles
Olga Baun,Peter Blümler +1 more
TL;DR: In this paper, a coaxial arrangement of two Halbach cylinders is proposed to guide superparamagnetic nano-particles on arbitrary trajectories over a large volume, where one magnet system provides a strong, homogeneous, dipolar magnetic field to magnetize and orient the particles, and a second constantly graded, quadrupolar field, superimposed on the first, generates a force on the oriented particles.
Journal ArticleDOI
On the magnetic aggregation of Fe3O4 nanoparticles.
TL;DR: The evolution of the mean length of aggregations as well as the completion time of the aggregation process in the nano and micro range is evaluated and could be useful to improve the magnetic nanoparticles assisted drug delivery method in order to minimize the side effects from the convectional cancer treatments.
Journal ArticleDOI
A numerical model for aggregations formation and magnetic driving of spherical particles based on OpenFOAM
TL;DR: This model is found suitable to predict the formation of aggregations and their motion under the influence of permanent and gradient magnetic fields, respectively, that are produced by an MRI device.
Journal ArticleDOI
Vinamax: a macrospin simulation tool for magnetic nanoparticles
TL;DR: Vinamax describes the influence of demagnetizing and anisotropy fields on magnetic nanoparticles at finite temperatures in a space- and time-dependent externally applied field.
References
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Book
Permanent Magnet and Electromechanical Devices: Materials, Analysis, and Applications
TL;DR: In this paper, the current model and charge model are compared with the charge model and the charge and torque model for magnetic field analysis, and the potential force and torque potential of magnetic fields are analyzed.
Journal ArticleDOI
The magnetofection method: using magnetic force to enhance gene delivery.
Christian Plank,Ulrike Schillinger,Franz Scherer,Christian Bergemann,Jean-Serge Remy,Florian Krötz,Martina Anton,Jim Lausier,Joseph Rosenecker +8 more
Abstract: In order to enhance and target gene delivery we have previously established a novel method, termed magnetofection, which uses magnetic force acting on gene vectors that are associated with magnetic particles. Here we review the benefits, the mechanism and the potential of the method with regard to overcoming physical limitations to gene delivery. Magnetic particle chemistry and physics are discussed, followed by a detailed presentation of vector formulation and optimization work. While magnetofection does not necessarily improve the overall performance of any given standard gene transfer method in vitro, its major potential lies in the extraordinarily rapid and efficient transfection at low vector doses and the possibility of remotely controlled vector targeting in vivo.
Journal ArticleDOI
Targeted delivery of magnetic aerosol droplets to the lung
Petra Dames,Petra Dames,Bernhard Gleich,Andreas W. Flemmer,Kerstin Hajek,Nicole Seidl,Frank Wiekhorst,Dietmar Eberbeck,Iris Bittmann,Christian Bergemann,Thomas Weyh,Lutz Trahms,Joseph Rosenecker,Carsten Rudolph,Carsten Rudolph +14 more
TL;DR: It is shown theoretically by computer-aided simulation, and for the first time experimentally in mice, that targeted aerosol delivery to the lung can be achieved with aerosol droplets comprising superparamagnetic iron oxide nanoparticles—so-called nanomagnetosols—in combination with a target-directed magnetic gradient field.
Journal ArticleDOI
Generation of magnetic nonviral gene transfer agents and magnetofection in vitro
TL;DR: This protocol can be used for cells that are difficult to transfect, such as primary cells, and may also be applied to viral nucleic acid delivery, and will be useful for screening vector compositions and novel magnetic nanoparticle preparations for optimized transfection efficiency in any cell type.