Open AccessJournal Article
Effect of arecoline on synaptosomal K+-phosphatase and (Na+ + K+)-ATPase.
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TLDR
Arecoline increased both the activity of K+-phosphatase in incubated synaptosomal fractions and the (Na+ + K+)-ATPase activity of synaptOSomal membranes by 40% and 78%, respectively, which is believed to be associated with increased ACh synthesis produced by arecoline.Abstract:
Synaptosomal fractions and synaptosomal membranes from rat brain tissue were prepared and characterized enzymatically. Arecoline increased both the activity of K+-phosphatase in incubated synaptosomal fractions and the (Na+ + K+)-ATPase activity of synaptosomal membranes by 40% and 78%, respectively. This activation of ion transport processes is believed to be associated with increased ACh synthesis produced by arecoline.read more
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Na+–K+-ACTIVATED ADENOSINETRIPHOSPHATASE AS A TRIGGER IN TRANSMITTER RELEASE
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Behavioral, physiological, and neuroendocrine responses to arecoline in normal twins and “well state” bipolar patients
John I. Nurnberger,David C. Jimerson,Susan Simmons-Alling,Carol A. Tamminga,N. Suzan Nadi,Dawn Lawrence,Natraj Sitaram,J. Christian Gillin,Elliot S. Gershon +8 more
TL;DR: Mood, behavioral, and neurochemical responses to arecoline, which appears to have nonspecific neurochemical effects at the dose employed, are not markers of vulnerability to affective illness.
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Arecoline-induced elevations of regional cerebral metabolism in the conscious rat.
TL;DR: Elevations in LCGU (measured after [14C]DG injection during peak behavior) in extrapyramidal regions, which mediate tremor, were related to the intensity of tremor and demonstrates the high sensitivity of this region to cholinomimetic stimulation.
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Increased ouabain binding after repeated noradrenergic stimulation
TL;DR: Prazosin, which, like piperoxane, activates presynaptic noradrenergic neurons but, unlike piper oxane, blocks postsynaptic receptors, did not increase K+-p-nitrophenylphosphatase, and decreased ouabain binding after 3 weeks.