Journal ArticleDOI
Effect of Dialysis Dose and Membrane Flux in Maintenance Hemodialysis
Garabed Eknoyan,Gerald J. Beck,Alfred K. Cheung,John T. Daugirdas,Tom Greene,John W. Kusek,Michael Allon,James L. Bailey,James A. Delmez,Thomas A. Depner,Johanna T. Dwyer,Andrew S. Levey,Nathan W. Levin,Edgar L. Milford,Daniel B. Ornt,Michael V. Rocco,Gerald Schulman,Steve J. Schwab,Brendan P. Teehan,Robert D. Toto +19 more
TLDR
Patients undergoing hemodialysis thrice weekly appear to have no major benefit from a higher dialysis dose than that recommended by current U.S. guidelines or from the use of a high-flux membrane.Abstract:
Background The effects of the dose of dialysis and the level of flux of the dialyzer membrane on mortality and morbidity among patients undergoing maintenance hemodialysis are uncertain. Methods We undertook a randomized clinical trial in 1846 patients undergoing thrice-weekly dialysis, using a two-by-two factorial design to assign patients randomly to a standard or high dose of dialysis and to a low-flux or high-flux dialyzer. Results In the standard-dose group, the mean (±SD) urea-reduction ratio was 66.3±2.5 percent, the single-pool Kt/V was 1.32±0.09, and the equilibrated Kt/V was 1.16±0.08; in the high-dose group, the values were 75.2±2.5 percent, 1.71±0.11, and 1.53±0.09, respectively. Flux, estimated on the basis of beta2-microglobulin clearance, was 3±7 ml per minute in the low-flux group and 34±11 ml per minute in the high-flux group. The primary outcome, death from any cause, was not significantly influenced by the dose or flux assignment: the relative risk of death in the high-dose group as com...read more
Citations
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Journal ArticleDOI
Hemofiltration and Hemodiafiltration Reduce Intradialytic Hypotension in ESRD
Francesco Locatelli,Paolo Altieri,Simeone Andrulli,Piergiorgio Bolasco,Giovanna Sau,Luciano A. Pedrini,Carlo Basile,Salvatore David,Mariano Feriani,Giovanni Montagna,Biagio Di Iorio,Bruno Memoli,Raffaella Cravero,Giovanni Giorgio Battaglia,Carmine Zoccali +14 more
TL;DR: Compared with conventional HD, convective therapies (HDF and HF) reduce ISH in long-term dialysis patients and shows a trend toward higher dropout for those who were assigned to HF.
Journal ArticleDOI
Impact of Pain and Symptom Burden on the Health-Related Quality of Life of Hemodialysis Patients
Sara N. Davison,Gian S. Jhangri +1 more
TL;DR: Symptom burden in end-stage renal disease was substantial and had a tremendous negative impact on all aspects of hemodialysis patients' HRQL, and these patients would likely benefit from the institution of programs to reduce symptom burden.
Journal ArticleDOI
Longitudinal Associations Between Dietary Protein Intake and Survival in Hemodialysis Patients
Christian S. Shinaberger,Ryan D. Kilpatrick,Deborah L. Regidor,Charles J. McAllister,Sander Greenland,Joel D. Kopple,Kamyar Kalantar-Zadeh +6 more
TL;DR: Low daily protein intake or decrease in its magnitude over time is associated with increased risk for death in MHD patients, and the association between time-varying protein intake and survival is causal or a consequence of anorexia secondary to MICS or other factors needs to be explored further in interventional trials.
Journal ArticleDOI
Decreased Number and Impaired Angiogenic Function of Endothelial Progenitor Cells in Patients with Chronic Renal Failure
Il Seok Cheon,Jin-Ho Choi,Koung Li Kim,Sung-Hea Kim,Kyungkee Baek,Shin Yi Jang,Jidong Sung,Wonhee Suh,Jonghoe Byun,Eun Seok Jeon,Beom Kim,Wooseong Huh,Ha Young Oh,Duk Kyung Kim +13 more
TL;DR: EPC biology, which is critical for neovascularization and the maintenance of vascular function, is altered in CRF, and dysfunction of circulating EPC has a role in the progression of cardiovascular disease in patients with CRF.
Journal ArticleDOI
EBPG guideline on dialysis strategies
James Tattersall,Alejandro Martin-Malo,Luciano A. Pedrini,Ali Basci,Bernard Canaud,Denis Fouque,Patrick Haage,Klaus Konner,Jeroen P. Kooman,Francesco Pizzarelli,Jan H.M. Tordoir,Marianne Vennegoor,Christoph Wanner,Piet M. ter Wee,Raymond Vanholder +14 more
TL;DR: Department of Renal Medicine, St James’s University Hospital, Leeds, UK, Nephrology Department, Reina Sofia University hospital, Cordoba, Spain, Division of Nephrology and Dialysis, Bolognini Hospital, Seriate, Italy.
References
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Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
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Generalized linear models. 2nd ed.
Peter McCullagh,John A. Nelder +1 more
TL;DR: A class of statistical models that generalizes classical linear models-extending them to include many other models useful in statistical analysis, of particular interest for statisticians in medicine, biology, agriculture, social science, and engineering.
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