Journal ArticleDOI
Effect of different cross-linking agents on the preparation of bovine serum albumin nanoparticles
Fatemeh Amighi,Fatemeh Amighi,Zahra Emam-Djomeh,Zahra Emam-Djomeh,Mohsen Labbafi-Mazraeh-Shahi +4 more
TLDR
In this paper, the authors investigated different cross-linkers, such as tannic acid, ascorbic acid and glucose crosslinker, to optimize albumin nanoparticles.Abstract:
Albumin nanoparticles are considerable in nanotechnology due to their high solubility in aqueous media, their ability to interact with various compounds, and their ease of nanoparticle tailoring from them. Due to the undesirable effects of glutaraldehyde (GT) as a cross-linker, the aim of this study was to investigate different cross-linking agents such as tannic acid, ascorbic acid, citric acid, sorbitol, and glucose (GLU) and to optimize particle production. For this purpose, final particle size, polydispersity index, and zeta potential were measured. Nanoparticles of different cross-linkers were compared to those prepared with GT using UV–Vis and FTIR spectra. Optimal conditions were defined as 20 mg/mL bovine serum albumin (BSA) solution (2 mL), pH 9, temperature of 4 °C, ethanol as desolvation agent, and GLU as cross-linker. BSA nanoparticles were obtained 125.1 nm in size, with a polydispersity index of 0.132 at the optimum point of the desolvation process. Studying FTIR and UV–Vis results showed that cross-linking occurred in the presence of all cross-linkers.read more
Citations
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Journal ArticleDOI
The Uniqueness of Albumin as a Carrier in Nanodrug Delivery.
Alessandra Spada,Alessandra Spada,Jaber Emami,Jaber Emami,Jack A. Tuszynski,Jack A. Tuszynski,Afsaneh Lavasanifar +6 more
TL;DR: In this paper, the importance of albumin as a nanodrug delivery carrier for hydrophobic drugs, taking advantage of the passive as well as active targeting potential of this nanocarrier.
Journal ArticleDOI
Serum Albumin Nanoparticles: Problems and Prospects.
TL;DR: In this article, the authors summarize the results regarding serum albumin-based nanoparticles (NPs) for drug delivery purposes, focusing on the relationship between their preparation techniques and synthesis parameters, as well as their successful clinical application.
Journal ArticleDOI
Albumin-Based Nanoparticles for the Delivery of Doxorubicin in Breast Cancer.
TL;DR: In this article, Nsuccinimidyl 3-(2-pyridyldithio) propionate (SPDP)-modified ABNs (ABN-SPDP) were evaluated for the preparation of Bovine Serum Albumin (BSA) nanoparticles.
Journal ArticleDOI
Albumin and functionalized albumin nanoparticles: production strategies, characterization, and target indications
Journal ArticleDOI
Fluorescent pattern recognition of metal ions by nanoparticles of bovine serum albumin as a chemical nose/tongue.
TL;DR: A sensor array mimicking a chemical nose/tongue based on bovine serum albumin nanoparticles (BSANsn) has been developed for the fluorescence pattern recognition of metal ions in biofluids and can distinguish 18 metal ions clearly at a concentration of as low as 10 μM.
References
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The effect of citric acid on the structural properties and cytotoxicity of the polyvinyl alcohol/starch films when molding at high temperature
TL;DR: In this article, a series of starch/polyvinyl alcohol (PVA) films, denoted SP films, with varying concentrations of citric acid (CA) were solvent cast at 140°C.