Journal ArticleDOI
Optimization of the preparation process for human serum albumin (HSA) nanoparticles.
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A pump-controlled preparation method was established which enabled particle preparation under defined conditions and the reproducibility of the particle size and particle size distribution under the proposed preparation conditions was demonstrated.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2003-05-12. It has received 644 citations till now. The article focuses on the topics: Particle size & Isoelectric point.read more
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Journal ArticleDOI
Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 2)
Soheyla Honary,Foruhe Zahir +1 more
TL;DR: The ability of employing zeta potential to target drug delivery systems to, and drug release at specific sites of the body are discussed.
Journal ArticleDOI
Albumin-based nanoparticles as potential controlled release drug delivery systems.
TL;DR: The current review embodies an in-depth discussion of albumin nanoparticles with respect to types, formulation aspects, major outcomes of in vitro and in vivo investigations as well as site-specific drug targeting using various ligands modifying the surface of albumins with special insights to the field of oncology.
Journal ArticleDOI
Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery
TL;DR: This review will focus on the nature of the polymers involved in the preparation of targeted nanocarriers, the synthesis methods to achieve the desired macromolecular architecture, the selected coupling strategy, and the choice of the homing molecules (vitamins, hormones, peptides, proteins, etc.), as well as the various strategies to display them at the surface of nanoccarriers.
Journal ArticleDOI
Challenges in Development of Nanoparticle-Based Therapeutics
TL;DR: Challenges likely to be encountered during the development and approval of nanoparticle-based therapeutics are summarized, and potential strategies for drug developers and regulatory agencies to accelerate the growth of this important field are discussed.
Journal ArticleDOI
Biopolymer-based nanoparticles for drug/gene delivery and tissue engineering.
Sachiko Nitta,Keiji Numata +1 more
TL;DR: In this article, a review of fabrication of biocompatible nanoparticles consisting of biopolymers such as protein (silk, collagen, gelatin, β-casein, zein and albumin), protein-mimicked polypeptides and polysaccharides (chitosan, alginate, pullulan, starch and heparin).
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PatentDOI
Measurement of protein using bicinchoninic acid
TL;DR: This new method maintains the high sensitivity and low protein-to-protein variation associated with the Lowry technique and demonstrates a greater tolerance of the bicinchoninate reagent toward such commonly encountered interferences as nonionic detergents and simple buffer salts.
Journal ArticleDOI
Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling
TL;DR: A new method for the size-distribution analysis of polymers by sedimentation velocity analytical ultracentrifugation that exploits the ability of Lamm equation modeling to discriminate between the spreading of the sedimentation boundary arising from sample heterogeneity and from diffusion is described.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
Book ChapterDOI
Structure of serum albumin.
Daniel C. Carter,Joseph X. Ho +1 more
TL;DR: This chapter provides an insight of the findings of past significant papers with the current knowledge of the recently determined high resolution X-ray structure of serum albumin and suggests that AFP may have a higher affinity for some unknown ligands important for fetal development.
Journal ArticleDOI
Size-distribution analysis of proteins by analytical ultracentrifugation: strategies and application to model systems.
TL;DR: It is shown that the least-squares approach ls-g*(s) can be extrapolated to infinite time by considering area divisions analogous to boundary divisions in the van Holde-Weischet method, thus allowing the transformation of interference optical data into an integral sedimentation coefficient distribution G(s).