Journal ArticleDOI
Effect of lithium chloride on spermatogenesis, testicular delta 5- 3 beta- and 17 beta-hydroxysteroid dehydrogenase activities in toad (Bufo melanostictus)
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The results of the present experiment suggest that lithium administration might be associated with significant adverse effects on testicular activity in toad.Abstract:
The purpose of the present study was to show the effects of lithium on testicular activities in the toad. Adult male toads were injected with lithium chloride (200 micrograms/toad) of alternate days for 21 days. At the moment of sacrifice on 22nd day, lithium treated animal showed decreases in testicular weight and Leydig cell nuclear area along with inhibition of spermatogenesis and testicular delta 5-3 beta as well as 17 beta-hydroxysteroid dehydrogenase activities. The results of our present experiment suggest that lithium administration might be associated with significant adverse effects on testicular activity in toad.read more
Citations
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Journal ArticleDOI
Testicular toxicity in sodium fluoride treated rats: association with oxidative stress.
TL;DR: The results of this experiment indicate that fluoride at a dose encountered in drinking water in contaminated areas exerts an adverse effect on the male reproductive system and this effect is associated with indicators of oxidative stress.
Journal ArticleDOI
Cadmium induced testicular pathophysiology: prophylactic role of taurine.
TL;DR: Data suggest that being an antioxidant, taurine plays a beneficial role against Cd-induced adverse effects on the male reproductive system.
Journal ArticleDOI
Waterborne fluoride exposure changed the structure and the expressions of steroidogenic-related genes in gonads of adult zebrafish (Danio rerio).
TL;DR: It is demonstrated that fluoride could significantly inhibit the growth of zebrafish, and notably affect the reproductive system in both sex zebra Fish by impairing the structure of ovary and testis, altering steroid hormone levels and steroidogenic genes expression related to the synthesis of sex hormones in zebra fish.
Journal ArticleDOI
Effects of lithium chloride on testicular steroidogenic and gametogenic functions in mature male albino rats
TL;DR: The results of the experiments suggest that lithium administration might be associated with significant adverse effects on testicular activities, and since hormonal changes and altered gametogenic activities were evident when plasma lithium concentration was below or within the therapeutic range, the data may have some potential clinical implications.
Journal ArticleDOI
Effect of human chorionic gonadotrophin coadministration on the activities of ovarian Δ5-3β-hydroxysteroid dehydrogenase, and 17β-hydroxysteroid dehydrogenase, and ovarian and uterine histology in lithium chloride-treated albino rats
TL;DR: It is concluded that hCG can protect ovarian steroidogenic and gametogenic function after lithium chloride treatment, and the duration of the oestrous cycle was increased in lithium chloride-treated rat with longer metestrous and diestrous phases.
References
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Journal ArticleDOI
Lithium in psychiatric therapy and prophylaxis.
TL;DR: An up-to-date, critical assessment of psychiatric lithium therapy and prophylactic action against endogenous affective disorder, including manic-depressive disorder and recurrent endogenous depressions is presented.
Journal ArticleDOI
Purification of a 17β-Hydroxysteroid Dehydrogenase of Human Placenta and Studies on Its Transhydrogenase Function
TL;DR: Methods for the extensive purification of a soluble 17@-hydroxysteroid dehydrogenasel of human placenta are described, which appears to be responsible for the entire 17/3estradiol-mediated transfer of hydrogen between pyridine nucleotides in soluble extracts of this tissue.
Journal ArticleDOI
Trophoblastic giant cells in placentas of rats and mice and their probable role in steroid-hormone production.
TL;DR: Other features of the giant cells indicating their function in the production of steroid hormones are a conspicuous amount of cytoplasmic lipid and a high capacity for making reduced triphosphopyridine nucleotide (TPNH) as a result of oxidation of glucose-6-phosphate.
Book ChapterDOI
Endocrine Side-Effects of Lithium
TL;DR: In this chapter most attention is paid to the depression of thyroid function, the only really significant endocrine side-effect of lithium treatment.
Journal ArticleDOI
The effects of purified gonadotrophins on the morphology of the testes and thumb pads of the normal and hypophysectomized autumn frog (Rana pipiens).
Mario H. Burgos,Aaron J. Ladman +1 more
TL;DR: The morphological and histochemical changes that are induced in the testes of the normal and hypophysectomized autumn frog by injection of human chorionic gonadotrophin (HCG) and of highly purified mammalian follicle-stimulating hormone (FSH), luteinizing hormone (LH), and luteotrophic hormones (LTH (prolactin).