Journal ArticleDOI
Effect of Myopia on the Thickness of the Retinal Nerve Fiber Layer Measured by Cirrus Hd Optical Coherence Tomography
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TLDR
The axial length affected the average R NFL thickness, and myopia affected the RNFL thickness distribution, which should be considered in diagnosing glaucoma.Abstract:
PURPOSE To evaluate the effect of myopia on the peripapillary retinal nerve fiber layer (RNFL) thickness measured by Cirrus HD optical coherence tomography (OCT). METHODS Comprehensive ophthalmic examinations were performed, including measurement of visual acuity, refraction, and axial length on 269 subjects (age, 19-26 years) with no ophthalmic abnormality. Further, 200 x 200-cube optic disc scans of the subjects' eyes were obtained with Cirrus HD OCT. The RNFL thickness at 256 points of the RNFL thickness profile and the average RNFL thickness were recorded. The correlations between these values and the axial length and spherical equivalent (SE) of refractive errors were then analyzed by simple linear regression, before and after adjustment of the ocular magnification. RESULTS Before ocular magnification adjustment, the uncorrected average RNFL thickness decreased as the axial length increased and as the SE decreased. However, after the adjustment, the corrected average RNFL thickness exhibited no correlation with the spherical equivalent and a weak positive correlation with the axial length. Myopia also affected the RNFL thickness distribution. As the axial length increased and the spherical equivalent decreased, the thickness of the temporal peripapillary RNFL increased and that of the superior, superior nasal, inferior, and inferior nasal peripapillary RNFL decreased. CONCLUSIONS The axial length affected the average RNFL thickness, and myopia affected the RNFL thickness distribution. High myopes are likely to exhibit different RNFL distribution patterns. Since ocular magnification significantly affects the RNFL measurement in such patients, it should be considered in diagnosing glaucoma.read more
Citations
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Journal ArticleDOI
Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a variability and diagnostic performance study.
Christopher Kai-Shun Leung,Carol Y. Cheung,Robert N. Weinreb,Quanliang Qiu,Quanliang Qiu,Shu Liu,Haitao Li,Guihua Xu,Guihua Xu,Ning Fan,Ning Fan,Lina Huang,Chi Pui Pang,Dennis S.C. Lam +13 more
TL;DR: Although the diagnostic performance and the strength of the structure-function association were comparable between Cirrus HD-OCT and Stratus OCT RNFL measurements, Cirrus' measurement variability demonstrated lower measurement variability compared withstratus OCT with significant differences at 1, 3, 4, and 8 to 11 o'clock.
Journal ArticleDOI
Profile and predictors of normal ganglion cell-inner plexiform layer thickness measured with frequency-domain optical coherence tomography.
Jean-Claude Mwanza,Mary K Durbin,Donald L. Budenz,Christopher A. Girkin,Christopher Kai-Shun Leung,Jeffrey M. Liebmann,James H. Peace,John S. Werner,Gadi Wollstein +8 more
TL;DR: The independent factors associated with thinner GCIPL include thinner RNFL, older age, longer ocular axial length, and being male.
Journal ArticleDOI
Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography: A Prospective Analysis of Age-Related Loss
Christopher Kai-Shun Leung,Marco Yu,Robert N. Weinreb,Cong Ye,Shu Liu,Gilda Lai,Dennis S.C. Lam +6 more
TL;DR: Progressive, age-related decline of RNFL thickness can be detected with longitudinal OCT imaging and rate estimates derived from trend analysis for detection of glaucomatous RNFL progression should be interpreted with reference to the normal ranges of age- related reduction, particularly when the baseline RNFL measurement is large.
Journal ArticleDOI
Effect of Race, Age, and Axial Length on Optic Nerve Head Parameters and Retinal Nerve Fiber Layer Thickness Measured by Cirrus HD-OCT
O'Rese J. Knight,Christopher A. Girkin,Donald L. Budenz,Donald L. Budenz,Mary K Durbin,William J. Feuer +5 more
TL;DR: There are racial differences in optic disc area, average cup-disc ratio, vertical cup-Disc ratio, cup volume, and RNFL thickness as measured by Cirrus HD-OCT.
Journal ArticleDOI
Axial Length Variation Impacts on Superficial Retinal Vessel Density and Foveal Avascular Zone Area Measurements Using Optical Coherence Tomography Angiography.
Danuta M. Sampson,Peijun Gong,Di An,Moreno Menghini,Alexander P. Hansen,David A. Mackey,David D. Sampson,Fred K. Chen +7 more
TL;DR: Ocular biometry should be performed with OCTA to correct image magnification error induced by axial length variation, and caution is advised when interpreting interocular and interindividual comparisons of SRVD and FAZA derived from OCTA without image size correction.
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The relationship between glaucoma and myopia: The blue mountains eye study
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Journal ArticleDOI
Determinants of Normal Retinal Nerve Fiber Layer Thickness Measured by Stratus OCT
Donald L. Budenz,Douglas R. Anderson,Rohit Varma,Joel S. Schuman,Louis B. Cantor,Jonathan Savell,David S. Greenfield,Vincent Michael Patella,Harry A. Quigley,James M. Tielsch +9 more
TL;DR: Retinal nerve fiber layer thickness, as measured by Stratus OCT, varies significantly with age, ethnicity, axial length, and optic disc area, and these variables may need to be taken into account when evaluating patients for diagnosis and follow-up of glaucoma.