Effect of non-steroidal anti-inflammatory drugs and prostaglandins on the permeability of the human small intestine.
TLDR
The studies show that non-steroidal anti-inflammatory drugs disrupt the intestinal barrier function in man and suggest that the morphological correlates of the damage may reside at the level of the intercellular junctions.Abstract:
Intestinal permeability was estimated in healthy subjects after ingestion of aspirin (12+12 g), ibuprofen (400+400 mg) and indomethacin (75+50 mg) at midnight and an hour before starting a 51chromium labelled ethylenediaminetetraacetate absorption test Intestinal permeability increased significantly from control levels following each drug and the effect was related to drug potency to inhibit cyclooxygenase Intestinal permeability increased to a similar extent after oral and rectal administration of indomethacin showing that the effect is systemically mediated Prostaglandin E2 decreased intestinal permeability significantly but failed to prevent the indomethacin induced increased intestinal permeability These studies show that non-steroidal anti-inflammatory drugs disrupt the intestinal barrier function in man and suggest that the morphological correlates of the damage may reside at the level of the intercellular junctionsread more
Citations
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Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans
TL;DR: The adverse effects of NSAIDs distal to the duodenum represent a range of pathologies that may be asymptomatic, but some are life threatening.
Journal ArticleDOI
Gastrointestinal Damage Associated with the Use of Nonsteroidal Antiinflammatory Drugs
TL;DR: Patients who take NSAIDs have an increased risk of nonspecific ulceration of the small-intestinal mucosa, which is less common than ulcers of the stomach or duodenum, but can lead to life-threatening complications.
Journal ArticleDOI
Zonulin and Its Regulation of Intestinal Barrier Function: The Biological Door to Inflammation, Autoimmunity, and Cancer
TL;DR: This new paradigm subverts traditional theories underlying the development of these diseases and suggests that these processes can be arrested if the interplay between genes and environmental triggers is prevented by reestablishing the zonulin-dependent intestinal barrier function.
Journal ArticleDOI
Human Intestinal Barrier Function in Health and Disease.
Julia König,Jerry M. Wells,Patrice D. Cani,Clara Lucia Garcia-Rodenas,Thomas T. MacDonald,Annick Mercenier,Jacqueline Whyte,Freddy J. Troost,Robert-Jan M. Brummer +8 more
TL;DR: The role of intestinal permeability in common disorders such as infections with intestinal pathogens, inflammatory bowel disease, irritable bowel syndrome, obesity, celiac disease, non-celiac gluten sensitivity, and food allergies will be discussed.
Journal ArticleDOI
A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy.
TL;DR: This study provides both biochemical and direct evidence of macroscopic injury to the small intestine in 68%-75% of volunteers resulting from 2 weeks' ingestion of slow-release diclofenac.
References
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Cytoprotection by prostaglandins.
TL;DR: A new property of PG was discovered, called "cytoprotection,"!' which designates the prop- erty of many PG to protect the mucosa of the stom- ach and the intestine from becoming inflamed and necrotic, when this mucosa is exposed to noxious agents.
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Barrier function of epithelia
TL;DR: An important role for active Na+ transport in the maintenance of the epithelial barrier function can be postulated after extensive electrophysiological and morphological work done in recent years.
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Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms.
TL;DR: Findings suggest that prostaglandins may play a significant role in the pathogenesis of gastric ulceration and may serve an important function in maintaining normal gastric mucosal integrity.
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Uptake and transport of macromolecules by the intestine: Possible role in clinical disorders (an update)
Ian R. Sanderson,W. Allan Walker +1 more
TL;DR: This review examines physiological transport of macromolecules through epithelia and through M cells and considers uncontrolled transport and its relation to disease states and the interrelationship between antigen transport and an altered immune system in the establishment of gastrointestinal disease.
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Temporal Relationship Between Cyclooxygenase Inhibition, as Measured by Prostacyclin Biosynthesis, and the Gastrointestinal Damage Induced by Indomethacin in the Rat
TL;DR: Investigation of inhibition of cyclooxygenase in the rat small intestine and gastric mucosa after subcutaneous administration of indomethacin found no temporal relationship between prostaglandin inhibition and the formation of lesions in the small intestine since the lesions became macroscopically apparent and developed at a time when cyclo oxygengenase inhibition was already declining.