Journal ArticleDOI
Effect of octreotide and erythromycin on idiopathic and scleroderma-associated intestinal pseudoobstruction.
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TLDR
It is concluded thatOctreotide and erythromycin relieve abdominal pain and nausea in pseudoobstruction and patients who have at least 5 AFs/4 hr after octreotide administration are most likely to clinically respond.Abstract:
Treatment of chronic intestinal pseudoobstruction with prokinetic agents has been disappointing. Our study was designed to determine if octreotide and erythromycin would provide sustained relief from nausea, abdominal pain, and bloating in pseudoobstruction. Using gastrointestinal manometry, quantitative parameters of the activity front of the migrating motor complex at baseline and after prokinetic therapy with erythromycin and octreotide were determined in 14 patients with intestinal pseudoobstruction who had nausea, abdominal pain, and bloating. Patients were treated with erythromycin and octreotide for 20–33 weeks. Octreotide increased the frequency, duration, and motility index of activity fronts (AFs) from 1.2±0.3 AFs/4hr, 2.7±0.7 min, and 85±23 min mm Hg to 4.1±0.8 AFs/4 hr, 5.5±0.7 min, and 152±24 min mm Hg, respectively (P<0.05). Antral activity was decreased from 63±14 to 23±8% by octreotide (P<0.05). Erythromycin induced antral activity; however, small intestinal motor activity was suppressed. While on erythromycin and octreotide, five patients had long-term improvement of nausea and abdominal pain. All responders had at least 5 AFs/4 hr induced by octreotide. We conclude that octreotide and erythromycin relieve abdominal pain and nausea in pseudoobstruction. Patients who have at least 5 AFs/4 hr after octreotide administration are most likely to clinically respond.read more
Citations
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Journal ArticleDOI
Update of EULAR recommendations for the treatment of systemic sclerosis
Otylia Kowal-Bielecka,Jaap Fransen,Jérôme Avouac,Mike O Becker,Mike O Becker,Agnieszka Kulak,Yannick Allanore,Oliver Distler,Philip J. Clements,Maurizio Cutolo,László Czirják,Nemanja Damjanov,Francesco Del Galdo,Christopher P. Denton,Jörg H W Distler,Ivan Foeldvari,Kim Figelstone,Marc Frerix,Daniel E. Furst,Serena Guiducci,Nicolas Hunzelmann,Dinesh Khanna,Marco Matucci-Cerinic,Ariane L. Herrick,Frank J. A. van den Hoogen,Jacob M van Laar,Gabriela Riemekasten,Richard M. Silver,Vanessa Smith,Vanessa Smith,Alberto Sulli,Ingo H. Tarner,Alan Tyndall,Joep Welling,Frederic Wigley,Gabriele Valentini,Ulrich A Walker,Francesco Zulian,Ulf Müller-Ladner +38 more
TL;DR: In this article, the European League against Rheumatism (EULAR) developed a set of recommendations for the treatment of systemic sclerosis (SSc) with attention to new therapeutic questions.
Journal ArticleDOI
American Gastroenterological Association technical review on the diagnosis and treatment of gastroparesis
TL;DR: A literature review and the recommendations herein were prepared for the American Gastroenterological Association Clinical Practice Committee and were approved by the Committee on May 16, 2004, and by the AGA Governing Board on September 23, 2004 as mentioned in this paper.
Journal Article
Technical review on the diagnosis and treatment of gastroparesis
TL;DR: This literature review and the recommendations herein were prepared for the American Gastroenterological Association Clinical Practice Committee and were approved by the Committee on May 16, 2004 and by the AGA Governing Board on September 23, 2004.
Journal ArticleDOI
EULAR recommendations for the treatment of systemic sclerosis: a report from the EULAR Scleroderma Trials and Research group (EUSTAR)
Otylia Kowal-Bielecka,Robert Landewé,Jérôme Avouac,S. Chwiesko,I. Miniati,L. Czirják,P. J. Clements,Christopher P. Denton,D. Farge,Kim Fligelstone,I. Földvari,Daniel E. Furst,Ulf Müller-Ladner,J. Seibold,Richard M. Silver,K. Takehara,B. Garay Toth,A Tyndall,Gabriele Valentini,F.H.J. van den Hoogen,Fredrick M. Wigley,Francesco Zulian,Marco Matucci-Cerinic +22 more
TL;DR: Evidence-based, consensus-derived recommendations for the treatment of systemic sclerosis are useful for rheumatologists to help guide treatment for patients with SSc and may also help to define directions for future clinical research in SSc.
Journal ArticleDOI
ESPEN guidelines on chronic intestinal failure in adults
Loris Pironi,Jann Arends,Federico Bozzetti,Cristina Cuerda,Lyn L. Gillanders,Palle Jeppesen,Francisca Joly,Darlene D. Kelly,Simon Lal,Michael Staun,Kinga Szczepanek,André Van Gossum,G. Wanten,Stéphane M. Schneider +13 more
TL;DR: These GLs have been devised to generate comprehensive recommendations for safe and effective management of adult patients with CIF and require complex technologies, multidisciplinary and multiprofessional activity, and expertise to care for both the underlying gastrointestinal disease and to provide HPN support.
References
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Journal ArticleDOI
A migrating electric complex of canine small intestine
TL;DR: A migrating electric complex that occurs in fasting dogs is described, composed of a consecutive series of slow waves, on each of which is superimposed a burst of Iargeamplitude action potentials that distinguish it from other electric activity in the small bowel of fasting dogs.
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The Interdigestive Motor Complex of Normal Subjects and Patients with Bacterial Overgrowth of the Small Intestine
TL;DR: These studies establish the presence and define the characteristics of the normal interdigestive motor complex in man and suggest that bacterial overgrowth may be due to a specific motility disorder i.e., complete or almost complete absence of the interdigested motor complex.
Journal ArticleDOI
The interdigestive myo-electric complex of the stomach and small bowel of dogs.
C F Code,J A Marlett +1 more
TL;DR: The period of intenseaction potential activity, the activity frot or band, was found to be one phase of a cyclic‐recurring sequence of changes in action potential activity.
Journal ArticleDOI
Effect of octreotide on intestinal motility and bacterial overgrowth in scleroderma.
TL;DR: Octreotide stimulates intestinal motility in normal subjects and in patients with scleroderma, and reduces bacterial overgrowth and improves abdominal symptoms, suggesting that intestinal activity evoked by octreotide is independent of motilin.
Journal ArticleDOI
Human interdigestive motility: variations in patterns from esophagus to colon.
TL;DR: Motility varied widely between and within individuals, and differences between normal patterns in the jejunum and ileum were particularly striking, suggesting levels of recordings must be defined accurately if putative abnormalities, of possible clinical significance, are to be interpreted correctly.