Effect of physical exercise on cortisol concentration and neutrophil oxygen metabolism in peripheral blood of horses
TLDR
The analysis showed that cortisol concentration was significantly higher post-exercise only in the blood of sport horses, suggesting that the magnitude of cortisol secretion is associated with the intensity and duration of exercise.Abstract:
The aim of the study was to evaluate the effect of regular physical exercise on cortisol concentration and oxygen-dependent bactericidal activity of neutrophils in peripheral blood in recreational and competitive sport horses (racehorses - Ra, trotters - T, jumping horses - J, driving horses - D). The study was conducted on 55 clinically healthy horses. Blood samples were collected from the external jugular vein three times: before exercise, immediately after exercise, and after 30-min rest. Blood samples were subjected to haematological examination, cortisol concentration was determined by radioimmunoassay (RIA) and neutrophil oxygen metabolism of neutrophils was determined using a chemiluminescence method. The analysis showed that cortisol concentration was significantly higher (P<0.05) post-exercise only in the blood of sport horses. This finding, along with a significant correlation (P<0.00005) with the heart and respiratory rates, suggests that the magnitude of cortisol secretion is associated with the intensity and duration of exercise. The relatively small post-exercise increase in cortisol concentration during different exercises of horses resulted in a transient increase of chemiluminescence activity of neutrophils, mainly in D (P<0.00001) and J horses (P<0.01). In the studied groups analysis of the correlation between cortisol concentration and other parameters showed significant correlation only in the case of the CL total in T (P<0.02) and D horses (P<0.004). It is therefore apparent that in a limited concentration, this hormone may stimulate the activity of these cells, although the effect of other neurohormonal factors cannot be excluded. This result confirms that regular and moderate training loads have a beneficial effect on the immunological status of horses.read more
Citations
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EQine nutrition and feeding
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Immune Response in Young Thoroughbred Racehorses under Training.
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Immune Functions Alterations Due to Racing Stress in Thoroughbred Horses
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Haematological profiles and erythrocyte fragility of Arabian stallions subjected to a 2000-m maximal race following administration of ergothioneine
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References
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TL;DR: A model which can satisfactorily account for all of the principal changes in the leucocyte count that have been noted during and after exercise is developed and some predictions are made that can be tested experimentally, and some experiments are suggested which should help elucidate the mode of action of catecholamines and cortisol.
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Endurance exercise causes interaction among stress hormones, cytokines, neutrophil dynamics, and muscle damage
Katsuhiko Suzuki,Manabu Totsuka,Shigeyuki Nakaji,Mutsuo Yamada,Satoru Kudoh,Qiang Liu,Kazuo Sugawara,Kanemitsu Yamaya,Koki Sato +8 more
TL;DR: The results indicate that stress-induced systemic release of bioactive substances may determine neutrophil mobilization and functional status, which then may affect local tissue damage of susceptible organs.