Journal ArticleDOI
Effect of plant sterols, fatty acids and lecithin on cholesterol absorption in vivo in the rat.
D Hollander,Donna Morgan +1 more
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TLDR
The inhibitory effect of plant sterols, fatty acids and lecithin on cholesterol intestnal absorption was studied in the unanesthetized rat using a single pass perfusion technique and is likely to have been caused by changes in cholesterol solubility in the micelle and shifts in the partition coefficient of cholesterol away from the cell membrane to themicelle.Abstract:
The inhibitory effect of plant sterols, fatty acids and lecithin on cholesterol intestnal absorption was studied in the unanesthetized rat using a single pass perfusion technique. Bile was excluded from the perfused intestine. Cholesterol absorption did not change following the additions of cholestanol, cholestanone, lanosterol, stigmasterol and β-sitosterol. A 3-fold increase in the molarity of cholestanol and β-sitosterol or the separate additions of the saturated short and medium chain fatty acids, butyric and octanoic, also did not change cholesterol absorption. The unsaturated long chain fatty acids, oleic, linoleic, linolenic and arachidonic, inhibited cholesterol absorption. Lecithin additions at concentrations of 0.1–1.5 mM caused a progressive, dose-related inhibition of cholesterol absorption. The inhibitory effect of these agents on cholesterol absorption is likely to have been caused by changes in cholesterol solubility in the micelle and shifts in the partition coefficient of cholesterol away from the cell membrane to the micelle.read more
Citations
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Journal ArticleDOI
Dietary Phospholipids and Intestinal Cholesterol Absorption
TL;DR: Experiments carried out with cultured cells and in experimental animals have consistently shown that phospholipids can inhibit intestinal cholesterol absorption, and limited evidence from clinical studies suggests that dietary PL supplementation has a similar effect in man.
Journal ArticleDOI
Some aspects of mechanism of inhibition of cholesterol absorption by β-sitosterol
Ikuo Ikeda,Michihiro Sugano +1 more
TL;DR: Results suggest that the restriction of the micellar solubility of cholesterol, rather than the inhibition of uptake from brush-border membrane, is the major determinant for the interference of beta-sitosterol with cholesterol absorption.
Journal ArticleDOI
Egg Phosphatidylcholine Decreases the Lymphatic Absorption of Cholesterol in Rats
TL;DR: The findings provide the first evidence that EPC markedly lowers the lymphatic absorption of cholesterol under in vivo conditions, suggesting that the intestinal absorption of egg cholesterol may be reduced by the presence of PC in egg yolk.
Journal ArticleDOI
Phospholipase A2 relieves phosphatidylcholine inhibition of micellar cholesterol absorption and transport by human intestinal cell line Caco-2
Reynold Homan,K. L. Hamelehle +1 more
TL;DR: The results indicate micellized cholesterol absorption by enterocytes is uniquely dependent on the elimination of micellar phosphatidylcholine and thus directlydependent on the lipolytic action of pancreatic phospholipase A2 (pPLA2) and therefore may be a new and novel class of cholesterol absorption inhibitors for therapeutic use.
Journal ArticleDOI
Protection against diet-induced obesity and obesity- related insulin resistance in Group 1B PLA2-deficient mice
TL;DR: A novel role for PLA(2) is suggested in the protection against diet-induced obesity and obesity-related insulin resistance, thereby offering a new target for treatment of obesity and diabetes.
References
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Journal ArticleDOI
Micelle Formation by Bile Salts: Physical-Chemical and Thermodynamic Considerations
Martin C. Carey,Donald Small +1 more
TL;DR: While bile salts increase slightly the solubility of relatively nonpolar molecules (such as cholesterol or fatty acids), they have a striking capacity to render soluble certain important insoluble molecules of biological importance such as phospholipids and monoglycerides.
Journal ArticleDOI
Plant sterols as cholesterol-lowering agents: Clinical trials in patients with hypercholesterolemia and studies of sterol balance
Ann M. Lees,Ann M. Lees,Henry Y.I. Mok,Henry Y.I. Mok,Robert S. Lees,Robert S. Lees,Martha A. McCluskey,Martha A. McCluskey,Scott M. Grundy,Scott M. Grundy +9 more
TL;DR: Sterol balance data showed that plant sterols inhibit cholesterol absorption with maximal negative cholesterol balance in adults at a dose of 3 g/day of a tall oil sterol suspension, which has potential value as an adjunct to dietary therapy in patients with mild hypercholesterolemia for whom long-term drug therapy is deemed advisable.
Journal ArticleDOI
The mechanism whereby bile acid micelles increase the rate of fatty acid and cholesterol uptake into the intestinal mucosal cell.
Henrik Westergaard,J M Dietschy +1 more
TL;DR: The experimental results were consistent both qualitatively and quantitatively with the third model indicating that the principle role of the micelle in facilitating lipid absorption is to overcome unstirred layer resistance while the actual process of fatty acid and cholesterol absorption occurs through a monomer phase in equilibrium with themicelle.
Journal ArticleDOI
The interaction of cholesterol absorption and cholesterol synthesis in man.
TL;DR: It is demonstrated that feedback control by dietary cholesterol does occur in man and there are important differences between man and various laboratory animals in regard to the interaction of absorption and synthesis as factors controlling the size of tissue pools of cholesterol.
Journal ArticleDOI
Cholestyramine resin therapy for hypercholesteremia: clinical and metabolic studies.
TL;DR: Cholestyramine resin, a bile-acid-sequestering agent, was administered to nine hypercholesteremic patients for periods of one month to four years and produced occasional gastrointestinal discomfort, but systemic side effects were not encountered.
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