Journal ArticleDOI
Effect of renal transplantation on sperm quality and sex hormone levels.
F. Akbari,Mohammad Alavi,A. Esteghamati,A.R. Mehrsai,Hooman Djaladat,R. Zohrevand,Gholamreza Pourmand +6 more
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TLDR
In this paper, the effect of successful renal transplantation on semen variables, sexual function and sex hormone profiles in a clinical trial was assessed, with an abbreviated version of the International Index of Erectile Function (IIEF), defined as a level of satisfaction of 4 or 5 on a 5-point scale.Abstract:
OBJECTIVE
To assess the effect of successful renal transplantation on semen variables, sexual function and sex hormone profiles in a clinical trial.
PATIENTS AND METHODS
Thirty patients on haemodialysis underwent renal transplantation; before and after surgery, their sperm density, motility and morphology were analysed, follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin and testosterone levels measured and compared, and sexual function assessed using an abbreviated version of the International Index of Erectile Function (IIEF), with a successful outcome defined as a level of satisfaction of 4 or 5 on a 5-point scale. The paired t-test was used to assess the statistically significance of differences in all analyses.
RESULTS
Sperm motility improved significantly (P < 0.001) but there were no significant changes in morphology or density (P = 0.33 and 0.068, respectively). Testosterone levels increased and FSH, LH and prolactin decreased significantly (P < 0.05) after renal transplantation. The IIEF showed that of the 30 patients, 14 were impotent before surgery and only six remained so afterward (P < 0.05).
CONCLUSION
Although sperm morphology and density did not improve after renal transplantation, there were highly significant changes in sperm motility. Hormonal levels in patients on haemodialysis improved after transplantation and returned to nearly normal; sexual function was also significantly better. Further studies are needed to confirm these results.read more
Citations
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Journal ArticleDOI
Reproduction and Transplantation: Report on the AST Consensus Conference on Reproductive Issues and Transplantation
TL;DR: This study highlights the need to understand more fully the pre- and post-transplant role of immune suppression in the selection and timing ofitoneal organ transplants.
Journal ArticleDOI
Osteoporosis after Solid Organ Transplantation
Naim M. Maalouf,Elizabeth Shane +1 more
TL;DR: The epidemiology of transplantation-related osteoporosis, the factors contributing to the pathogenesis of this complication, and the evaluation, prevention, and treatment options available for kidney, liver, lung, and heart transplant recipients are reviewed.
Journal ArticleDOI
Sexual Function in Chronic Kidney Disease
TL;DR: Treatment strategies include optimizing dose of dialysis, correction of anemia with erythropoietin, and correction of hyperparathyroidism, and Successful kidney transplantation may restore normal sexual function, especially in younger patients.
Journal ArticleDOI
Pregnancy after Kidney Transplantation
TL;DR: Information is discussed to help the physician counsel the kidney transplant recipient about risks of pregnancy for the mother and the fetus and information is provided to help guide treatment of the pregnant transplant recipient.
Journal ArticleDOI
Gonadal dysfunction in men with chronic kidney disease: clinical features, prognostic implications and therapeutic options
TL;DR: There are encouraging data suggesting plausible benefits from testosterone replacement therapy, however, further studies are needed with regards to safety and effectiveness of this therapy.
References
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Journal ArticleDOI
The Pituitary-Testicular Axis in Men with Chronic Renal Failure
TL;DR: Chronic renal failure interferes with testicular steroid production and spermatogenesis, and the effects of uremia on the pituitary-testicular axis in 35 men with creatinine clearances less than 4 ml per minute per 1.7m was studied.
Journal ArticleDOI
Hypothalamic-pituitary gonadal dysfunction in renal failure, dialysis and renal transplantation.
TL;DR: This review summarizes available knowledge of the function of the hypothalamic-pituitary gonadal axis in uremia and specific emphasis is directed towards the derangements of testicular function in u Remia and the central as well as gonadal disturbances operative.
Journal ArticleDOI
Gonadal dysfunction in uremic men. A study of the hypothalamo-pituitary-testicular axis before and after renal transplantation.
Victoria S. Lim,Victor S. Fang +1 more
TL;DR: It is postulated that a defect in that portion of the hypothalamus involved in the receipt and/or interpretation of message might be at fault in uremia.
Journal ArticleDOI
Sexual dysfunction in the male patient with uremia: A reappraisal
TL;DR: Data indicate that 50% of male patients with Uremia have partial or complete impotence, which is most probably organic in nature and is related to uremia or its metabolic or hormonal consequences rather than to the state of chronic illness.
Journal ArticleDOI
Male reproductive function in uraemia: efficacy of haemodialysis and renal transplantation.
TL;DR: The impairment of testicular function seen in advanced uraemia is not reversible by maintenance haemodialysis, and after successful transplantation, steroidogenic function became almost normal while spermatogenic function showed a striking if incomplete recovery.