Journal ArticleDOI
Effect of Standard and High-Fat Diets during Modeling of Streptozotocin-Induced Diabetes in Rats on the Development of Complications.
Elvira R. Shaykhutdinova,V. A. Palikov,Y. A. Palikova,N. A. Borozdina,I. N. Kravchenko,E. S. Sadovnikova,I. A. Pakhomova,P. A. Rudenko,V. A. Kazakov,T. Y. Zharmukhamedova,O. N. Khokhlova,Igor A. Dyachenko +11 more
TLDR
For evaluation of the effect of high-fat diet on the development of diabetic complications, the rats were maintained on standard or highfat diet for 3 weeks and the results showed significant changes in hematological parameters, physical and biochemical parameters of the urine, and in development of thermal allodynia were different after 15-week standard and high fat diets as mentioned in this paper.Abstract:
For evaluation of the effect of high-fat diet on the development of diabetic complications, the rats were maintained on standard or high-fat diet. In 3 weeks, diabetes mellitus was modeled by single intraperitoneal injection of streptozotocin. Changes in hematological parameters, physical and biochemical parameters of the urine, and in the development of thermal allodynia were different after 15-week standard and high-fat diets.read more
Citations
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Search for Promising Strains of Probiotic Microbiota Isolated from Different Biotopes of Healthy Cats for Use in the Control of Surgical Infections
Pavel Rudenko,Pavel Rudenko,Yuriy Vatnikov,Nadezhda Sachivkina,A.A. Rudenko,Evgeny Vladimirovich Kulikov,Vladimir Ivanovich Lutsay,Elena Notina,Irina Bykova,Aleksander Petrov,Stanislav Drukovskiy,Ifarajimi Rapheal Olabode +11 more
TL;DR: In this article, the results of the isolation of indigenous microbiota from various biotopes of healthy cats, as well as the study of their biological marker properties for the selection of the most optimal strains in probiotic medicines for the control of surgical infections.
Journal ArticleDOI
The role of lipid peroxidation products and antioxidant enzymes in the pathogenesis of aseptic and purulent inflammation in cats.
Pavel Rudenko,Pavel Rudenko,Yuriy Vatnikov,Sergey Engashev,Andrey Kvochko,Elena Notina,Irina Bykova,Evgeny Vladimirovich Kulikov,Andrey Rudenko,Olesia Anatolievna Petrukhina,Viktoriya B. Rudenko +10 more
TL;DR: In this paper, the state of antioxidant protection was assessed by indi¬cators of superoxide dismutase (SOD) activity, catalase (CT), ceruloplasmin (CP) concentration, glutathione peroxidase activity, and total antioxidant activity (AOA).
Journal ArticleDOI
Fecal Microbiota Analysis in Cats with Intestinal Dysbiosis of Varying Severity
N. S. Bugrov,Pavel Rudenko,Vladimir Ivanovich Lutsay,Regina Gurina,Andrey N. Zharov,Nadiya I. Khairova,Maria S. Molchanova,E.A. Krotova,M.I. Shopinskaya,M. V. Bolshakova,Irina Popova +10 more
TL;DR: In this article , a detailed analysis of the quantitative and qualitative fecal microbiota spectrum in cats with intestinal dysbiosis of varying severity was performed and the data obtained indicate that, depending on the severity in cats, the intestinal microbiome landscape changes significantly, there is a shift in the balance between the Gram-positive and Gram-negative bacterial pools and in the nature of the isolation of specific bacteria forms.
Journal ArticleDOI
Low molecular weight NGF mimetic GK‐2 normalizes the parameters of glucose and lipid metabolism and exhibits a hepatoprotective effect on a prediabetes model in obese Wistar rats
Ivanov Sv,Ostrovskaya Ru,Kolyasnikova Kn,Alchinova Ib,M. S. Demorzhi,Gudasheva Ta,Seredenin Sb +6 more
TL;DR: GK‐2 reduced the degree of abdominal obesity to the level of the healthy animals and eliminated morphological abnormalities in the liver caused by the HFD, determining the feasibility of further GK‐ 2 research as a potential agent for prediabetes treatment.
Journal ArticleDOI
Comparison of Biochemical Parameters and Pathomorphological Changes in Rats Receiving Standard and High-Fat Diets during Modeling of Streptozotocin Diabetes
Natalya A. Borozdina,Elvira R. Shaykhutdinova,V. A. Palikov,Yulia A. Palikova,E. N. Kazakova,E. S. Sadovnikova,V. A. Kazakov,Oksana Sintsova,Igor A. Dyachenko +8 more
References
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Journal ArticleDOI
The Characterization of High-Fat Diet and Multiple Low-Dose Streptozotocin Induced Type 2 Diabetes Rat Model
TL;DR: Results indicated that high-fat diet combined with multiple low doses of STZ (30 mg/kg at weekly intervals for 2 weeks) proved to be a better way for developing a stable animal model of type 2 diabetes, and this new model may be suitable for pharmaceutical screening.
Journal ArticleDOI
Diabetic Microvascular Disease: An Endocrine Society Scientific Statement.
Eugene J. Barrett,Zhenqi Liu,Mogher Khamaisi,George L. King,Ronald Klein,Barbara E.K. Klein,Timothy M. Hughes,Suzanne Craft,Barry I. Freedman,Donald W. Bowden,Aaron I. Vinik,Carolina Casellini +11 more
TL;DR: It is disappointing that microvascular complications of diabetes continue to compromise the quantity and quality of life for patients with diabetes, and by understanding and building on current research findings, new approaches for prevention and treatment that will be effective for future generations are discovered.
Journal ArticleDOI
High-fat diet and streptozotocin in the induction of type 2 diabetes mellitus: a new proposal
Diego A De Magalhães,Willian Tsuyoshi Kume,Francyele Dos Santos Correia,Thaís S Queiroz,Edgar Wilibaldo Allebrandt Neto,Maísa Pavani dos Santos,Nair Honda Kawashita,Suélem Aparecida de França +7 more
TL;DR: The combination of high-fat diet with STZ (i.p) generated rats with hyperglycemia associated with hypertriglyceridemia and introduced many other alterations present in human DM2.
Journal ArticleDOI
Rosmarinic acid ameliorates hyperglycemia and insulin sensitivity in diabetic rats, potentially by modulating the expression of PEPCK and GLUT4.
Joshua Runtuwene,Kai-Chun Cheng,Akihiro Asakawa,Haruka Amitani,Marie Amitani,Akinori Morinaga,Yoshiyuki Takimoto,Bernabas Harold Ralph Kairupan,Akio Inui +8 more
TL;DR: RA reduces hyperglycemia and ameliorates insulin sensitivity by decreasing PEPCK expression and increasing GLUT4 expression.
Journal ArticleDOI
Characterisation of Pain Responses in the High Fat Diet/Streptozotocin Model of Diabetes and the Analgesic Effects of Antidiabetic Treatments
TL;DR: The demonstration that currently prescribed antidiabetic drugs prevent aberrant pain behaviour supports the use of this model to investigate pain mechanisms associated with diabetes.