Diabetic Microvascular Disease: An Endocrine Society Scientific Statement.
Eugene J. Barrett,Zhenqi Liu,Mogher Khamaisi,George L. King,Ronald Klein,Barbara E.K. Klein,Timothy M. Hughes,Suzanne Craft,Barry I. Freedman,Donald W. Bowden,Aaron I. Vinik,Carolina Casellini +11 more
TLDR
It is disappointing that microvascular complications of diabetes continue to compromise the quantity and quality of life for patients with diabetes, and by understanding and building on current research findings, new approaches for prevention and treatment that will be effective for future generations are discovered.Abstract:
Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs. Our understanding of the genesis of this injury and of potential interventions to prevent, limit, or reverse injury/dysfunction is continuously evolving. This statement reviews biochemical/cellular pathways involved in facilitating and abrogating microvascular injury. The statement summarizes the types of injury/dysfunction that occur in the three classical diabetes microvascular target tissues, the eye, the kidney, and the peripheral nervous system; the statement also reviews information on the effects of diabetes and insulin resistance on the microvasculature of skin, brain, adipose tissue, and cardiac and skeletal muscle. Despite extensive and intensive research, it is disappointing that microvascular complications of diabetes continue to compromise the quantity and quality of life for patients with diabetes. Hopefully, by understanding and building on current research findings, we will discover new approaches for prevention and treatment that will be effective for future generations.read more
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Worldwide estimates of incidence, prevalence and mortality of type 1 diabetes in children and adolescents: Results from the International Diabetes Federation Diabetes Atlas, 9th edition.
Christopher Patterson,Suvi Karuranga,Paraskevi Salpea,Pouya Saeedi,Gisela Dahlquist,Gyula Soltész,Graham D. Ogle +6 more
TL;DR: Worldwide estimates of numbers of children and adolescents with type 1 diabetes continue to increase, but prevalence estimates have decreased in the sub-Saharan Africa because allowance has been made for increased mortality in those with diabetes.
Journal ArticleDOI
Methylglyoxal, a highly reactive dicarbonyl compound, in diabetes, its vascular complications and other age-related diseases
TL;DR: The mechanisms through which MGO is formed, its detoxification by the glyoxalase system, and its effect on biochemical pathways in relation to the development of diabetes, vascular complications of diabetes and other age-related diseases are summarized.
Journal Article
Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes
Carolina E. Hagberg,Annika Mehlem,Annelie Falkevall,Lars Muhl,Barbara C Fam,Henrik Ortsäter,Pierre Scotney,Daniel Nyqvist,Erik Samén,Li Lu,Sharon Stone-Elander,Joseph Proietto,Sofianos Andrikopoulos,Åke Sjöholm,Andrew D. Nash,Ulf Eriksson +15 more
TL;DR: In this article, the authors proposed VEGF-B antagonism as a novel pharmacological approach for type 2 diabetes, targeting the lipidtransport properties of the endothelium to improve muscle insulin sensitivity and glucose disposal.
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Cerebral microvascular complications of type 2 diabetes : stroke, cognitive dysfunction, and depression
Thomas T. van Sloten,Sanaz Sedaghat,Mercedes R. Carnethon,Lenore J. Launer,Coen D.A. Stehouwer +4 more
TL;DR: Cerebral outcomes in diabetes might be improved following treatments targeting the pathways through which diabetes damages the microcirculation, which might include drugs that reduce dicarbonyl compounds, augment cerebral insulin signalling, or improve blood-brain barrier permeability and cerebral vasoreactivity.
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TL;DR: In this article, the effects of intensive blood-glucose control with either sulphonylurea or insulin and conventional treatment on the risk of microvascular and macrovascular complications in patients with type 2 diabetes in a randomised controlled trial were compared.
Journal Article
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group.
R C Turner,C Fox,Matthews,H McElroy,Carole A. Cull,Rury R. Holman,P. A. Neil,D R Hadden,D Wright,E Manley,Irene M Stratton,UK Prospective Diabetes,E M Kohner,Frighi,Michael Gnant +14 more
TL;DR: The effects of intensive blood-glucose control with either sulphonylurea or insulin and conventional treatment on the risk of microvascular and macrovascular complications in patients with type 2 diabetes in a randomised controlled trial were compared.
Journal ArticleDOI
Biochemistry and molecular cell biology of diabetic complications
TL;DR: This integrating paradigm provides a new conceptual framework for future research and drug discovery in diabetes-specific microvascular disease and seems to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain.