J
James E. Evans
Researcher at Roskamp Institute
Publications - 88
Citations - 5408
James E. Evans is an academic researcher from Roskamp Institute. The author has contributed to research in topics: Meibomian gland & Medicine. The author has an hindex of 33, co-authored 81 publications receiving 4882 citations. Previous affiliations of James E. Evans include University of Massachusetts Medical School & University of Massachusetts Amherst.
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Journal ArticleDOI
Molecular identification of a danger signal that alerts the immune system to dying cells
TL;DR: Uric acid stimulates dendritic cell maturation and, when co-injected with antigen in vivo, significantly enhances the generation of responses from CD8+ T cells, and have important implications for vaccines, autoimmunity and inflammation.
Journal ArticleDOI
Androgen Deficiency, Meibomian Gland Dysfunction, and Evaporative Dry Eye
David A. Sullivan,David A. Sullivan,Benjamin Sullivan,James E. Evans,F Schirra,F Schirra,H. Yamagami,H. Yamagami,Meng Liu,Meng Liu,Stephen M. Richards,Tomo Suzuki,Tomo Suzuki,Debra A. Schaumberg,Debra A. Schaumberg,Debra A. Schaumberg,Rose M. Sullivan,Reza Dana,Reza Dana +18 more
TL;DR: The results support the hypothesis that androgen deficiency may be an important etiologic factor in the pathogenesis of evaporative dry eye in women with Sjögren's syndrome and demonstrate that the meibomian gland is an androgen target organ.
Journal ArticleDOI
Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma.
John A. Bowden,Alan Heckert,Candice Z. Ulmer,Christina M. Jones,Jeremy P. Koelmel,Laila Abdullah,Linda Ahonen,Yazen Alnouti,Aaron M. Armando,John M. Asara,John M. Asara,Takeshi Bamba,John R. Barr,Jonas Bergquist,Christoph H. Borchers,Joost Brandsma,Susanne B. Breitkopf,Tomas Cajka,Amaury Cazenave-Gassiot,Antonio Checa,Michelle Cinel,Romain A. Colas,Serge Cremers,Edward A. Dennis,James E. Evans,Alexander Fauland,Oliver Fiehn,Oliver Fiehn,Michael S. Gardner,Timothy J. Garrett,Katherine H. Gotlinger,Jun Han,Yingying Huang,Aveline H. Neo,Tuulia Hyötyläinen,Yoshihiro Izumi,Hongfeng Jiang,Houli Jiang,Jiang Jiang,Maureen Kachman,Reiko Kiyonami,Kristaps Klavins,Christian Klose,Harald Köfeler,Johan Kolmert,Therese Koal,Grielof Koster,Zsuzsanna Kuklenyik,Irwin J. Kurland,Michael Leadley,Karen Lin,Krishna Rao Maddipati,Danielle J. McDougall,Peter J. Meikle,Natalie A. Mellett,Cian Monnin,M. Arthur Moseley,Renu Nandakumar,Matej Orešič,Rainey E. Patterson,David A. Peake,Jason S. Pierce,Martin Post,Anthony D. Postle,Rebecca S. Pugh,Yunping Qiu,Oswald Quehenberger,Parsram Ramrup,Jon Rees,Barbara Rembiesa,Denis Reynaud,Mary R. Roth,Susanne Sales,Kai Schuhmann,Michal L. Schwartzman,Charles N. Serhan,Andrej Shevchenko,Stephen E. Somerville,Lisa St. John-Williams,Michal A. Surma,Hiroaki Takeda,Rhishikesh Thakare,J. Will Thompson,Federico Torta,Alexander Triebl,Martin Trötzmüller,S. J. Kumari A. Ubhayasekera,Dajana Vuckovic,Jacquelyn M. Weir,Ruth Welti,Markus R. Wenk,Craig E. Wheelock,Libin Yao,Min Yuan,Xueqing Zhao,Senlin Zhou +95 more
TL;DR: The central theme of the interlaboratory study was to provide values to help harmonize lipids, lipid mediators, and precursor measurements across the community, and it was also initiated to stimulate a discussion regarding areas in need of improvement.
Journal ArticleDOI
Effect of androgen deficiency on the human meibomian gland and ocular surface
Kathleen L. Krenzer,Reza Dana,Reza Dana,M. David Ullman,Jennifer M. Cermak,Jennifer M. Cermak,Dorothy Bazzinotti Tolls,James E. Evans,David A. Sullivan +8 more
TL;DR: The results demonstrate that patients taking antiandrogen treatment had a significant increase in the frequency of appearance of tear film debris, an abnormal tear film meniscus, irregular posterior lid margins, conjunctival tarsal injection, and orifice metaplasia of the meibomian glands.
Journal Article
Androgen influence on the meibomian gland.
David A. Sullivan,Benjamin Sullivan,M. David Ullman,Eduardo Rocha,Kathleen L. Krenzer,Kathleen L. Krenzer,Jennifer M. Cermak,Ikuko Toda,Marshall G. Doane,James E. Evans,L. Alexandra Wickham +10 more
TL;DR: The findings show that the meibomian gland is an androgen target organ and that androgens influence the lipid profile within this tissue, however, the extent to which androgens regulate the production of these lipids and whether this action may impact tear film stability remain to be determined.