Effect of Weight Loss by Gastric Bypass Surgery Versus Hypocaloric Diet on Glucose and Incretin Levels in Patients with Type 2 Diabetes
Blandine Laferrère,Julio Teixeira,James McGinty,Hao Tran,Joseph R. Egger,Antonia Colarusso,Betty Kovack,Baani Bawa,Ninan Koshy,Hongchan Lee,Kimberly Yapp,Blanca Oliván +11 more
TLDR
Early after Gastric bypass surgery, the greater GLP-1 and GIP release and improvement of incretin effect are related not to weight loss but rather to the surgical procedure, which could be responsible for better diabetes outcome after GBP.Abstract:
Context: Gastric bypass surgery (GBP) results in rapid weight loss, improvement of type 2 diabetes (T2DM), and increase in incretins levels. Diet-induced weight loss also improves T2DM and may increase incretin levels. Objective: Our objective was to determine whether the magnitude of the change of the incretin levels and effect is greater after GBP compared with a low caloric diet, after equivalent weight loss. Design and Methods: Obese women with T2DM studied before and 1 month after GBP (n = 9), or after a diet-induced equivalent weight loss (n = 10), were included in the study. Patients from both groups were matched for age, body weight, body mass index, diabetes duration and control, and amount of weight loss. Setting: This outpatient study was conducted at the General Clinical Research Center. Main Outcome Measures: Glucose, insulin, proinsulin, glucagon, gastric inhibitory peptide (GIP), and glucagon-like peptide (GLP)-1 levels were measured after 50-g oral glucose. The incretin effect was measured...read more
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Clinical Practice Guidelines for the Perioperative Nutritional, Metabolic, and Nonsurgical Support of the Bariatric Surgery Patient—2013 Update: Cosponsored by American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic & Bariatric Surgery
Jeffrey I. Mechanick,Adrienne Youdim,Daniel B. Jones,W. Timothy Garvey,Daniel L. Hurley,M. Molly McMahon,Leslie J. Heinberg,Robert F. Kushner,Ted D. Adams,Scott A. Shikora,John Dixon,Stacy A. Brethauer +11 more
TL;DR: These updated guidelines reflect recent additions to the evidence base and include Examples of expanded topics in this update include: the roles of sleeve gastrectomy, bariatric surgery in patients with type‐2 diabetes,bariatric surgery for patients with mild obesity, copper deficiency, informed consent, and behavioral issues.
Journal ArticleDOI
Bariatric Surgery versus Conventional Medical Therapy for Type 2 Diabetes
Geltrude Mingrone,Simona Panunzi,Andrea De Gaetano,Caterina Guidone,Amerigo Iaconelli,Laura Leccesi,Giuseppe Nanni,Alfons Pomp,Marco Castagneto,Giovanni Ghirlanda,Francesco Rubino +10 more
TL;DR: In severely obese patients with type 2 diabetes, bariatric surgery resulted in better glucose control than did medical therapy and preoperative BMI and weight loss did not predict the improvement in hyperglycemia after these procedures.
Journal ArticleDOI
European Guidelines for Obesity Management in Adults
Volkan Yumuk,Constantine Tsigos,Martin Fried,Karin Schindler,Luca Busetto,Dragan Micic,Hermann Toplak +6 more
TL;DR: It is concluded that physicians have a responsibility to recognise obesity as a disease and help obese patients with appropriate prevention and treatment and focus on realistic goals and lifelong multidisciplinary management.
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Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol
E. L. Lim,Kieren G. Hollingsworth,Benjamin S. Aribisala,M J. Chen,John C. Mathers,Roy Taylor +5 more
TL;DR: Normalisation of both beta cell function and hepatic insulin sensitivity in type 2 diabetes was achieved by dietary energy restriction alone, and was associated with decreased pancreatic and liver triacylglycerol stores.
References
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Journal ArticleDOI
Bariatric surgery. A systematic review and meta-analysis
TL;DR: Effective weight loss was achieved in morbidly obese patients after undergoing bariatric surgery, and a substantial majority of patients with diabetes, hyperlipidemia, hypertension, and obstructive sleep apnea experienced complete resolution or improvement.
Journal ArticleDOI
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