Journal ArticleDOI
Effects of α-TCP and TetCP on MC3T3-E1 proliferation, differentiation and mineralization
Atsushi Ehara,Korenori Ogata,Satoshi Imazato,Shigeyuki Ebisu,Takayoshi Nakano,Yukichi Umakoshi +5 more
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TLDR
The results of the present study indicate that α -TCP and TetCP promote osteogenesis by increasing collagen synthesis and calcification of the extra-cellular matrix.About:
This article is published in Biomaterials.The article was published on 2003-02-01. It has received 168 citations till now. The article focuses on the topics: Osteoblast & Tetracalcium phosphate.read more
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A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics
TL;DR: This review comprehensively covers literature reports which have investigated specifically the effect of dissolution products of silicate bioactive glasses and glass-ceramics in relation to osteogenesis and angiogenesis and focuses on the ion release kinetics of the materials and the specific effect of the released ionic dissolution products on human cell behaviour.
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Significance of calcium phosphate coatings for the enhancement of new bone osteogenesis – A review ☆
TL;DR: A systematic analysis of results available from in vitro, in vivo and clinical trials on the effects of biocompatible calcium phosphate (CaP) coatings is presented and the future research and use of these devices is discussed.
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α-Tricalcium phosphate: Synthesis, properties and biomedical applications
TL;DR: It is as biocompatible as β-TCP, but more soluble, and hydrolyses rapidly to calcium-deficient hydroxyapatite, which makes α- TCP a useful component for preparing self-setting osteotransductive bone cements and biodegradable bioceramics and composites for bone repairing.
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Pyrophosphate Inhibits Mineralization of Osteoblast Cultures by Binding to Mineral, Up-regulating Osteopontin, and Inhibiting Alkaline Phosphatase Activity
TL;DR: PPi prevents mineralization in MC3T3-E1 osteoblast cultures by at least three different mechanisms that include direct binding to growing crystals, induction of Opn expression, and inhibition of Tnap activity.
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Functionally graded electrospun polycaprolactone and beta-tricalcium phosphate nanocomposites for tissue engineering applications.
TL;DR: The demonstrated hybrid method should allow much better control of the distributions of various ingredients, including the concentrations of drugs/growth factors, as well as the porosity, mechanical property, wettability, biodegradation rate distributions in tissue engineering scaffolds, aiming to mimic the elegant complex distributions found in native tissue.
References
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In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria
TL;DR: Results indicate that clonal osteogenic cell line MC3T3-E1 cells have the capacity to differentiate into osteoblasts and osteocytes and to form calcified bone tissue in vitro.
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Calcium orthophosphates in medicine: from ceramics to calcium phosphate cements.
TL;DR: The main goal of this article is to provide a simple, but comprehensive presentation of CaP compounds.
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Metabolic regulation via intracellular pH.
TL;DR: It is suggested that pHi functions as a synergistic messenger, providing a metabolic context within and through which the actions of other effectors are integrated, and changes in adenylate energy charge can significantly alter pHi.
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Isolation and characterization of MC3T3-E1 preosteoblast subclones with distinct in vitro and in vivo differentiation/mineralization potential.
Dian Wang,Kurt D. Christensen,Kanwal Chawla,Guozhi Xiao,Paul H. Krebsbach,Renny T. Franceschi +5 more
TL;DR: Interestingly, subclones with both high and low differentiation potential produced similar amounts of collagen in culture and expressed comparable basal levels of mRNA encoding Osf2/Cbfa1, an osteoblast‐related transcription factor, and there was no clear relationship between levels of this message and induction of mRNAs for other differentiation markers.
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Osteoblast and chondroblast differentiation.
TL;DR: This work focuses on the osteoprogenitors that divide and differentiate into mature OBs forming bone nodules in fetal rat calvaria cell cultures, and uses cellular, immunocytochemical, and molecular approaches, including PCR on small numbers of cells, to discriminate stages.