Journal ArticleDOI
Effects of corticoid agonists and antagonists on apical Na+ permeability of toad urinary bladder
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TLDR
At least one-third of the natriferic action of aldosterone measured in the amphibian urinary bladder is mediated by the glucocorticoid receptor, however, some of the effects observed cannot be accounted for by a simple receptor occupancy-response scheme.Abstract:
Effects of RU-28362 (glucocorticoid agonist), RU-38486 (glucocorticoid antagonist), and RU-26752 (mineralocorticoid antagonist) on the apical Na+ permeability of toad bladder were measured and corr...read more
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Journal ArticleDOI
Regulation of sgk by aldosterone and its effects on the epithelial Na(+) channel.
TL;DR: regulation of sgk by aldosterone in native mammalian epithelia and its effect on ENaC are characterized to suggest that the response is mediated, at least in part, by occupancy of the mineralocorticoid receptor.
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Transcriptional control of sodium transport in tight epithelial by adrenal steroids.
TL;DR: Observations suggest that a bimodal stimulation of Na transport could involve two different gene networks which are directly and independently stimulated by the action of the hormone-receptor complex and the following “molecular” cascades.
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Insights Into Glucocorticoid-Associated Hypertension.
TL;DR: The association between excess glucocorticoids and hypertension has been much discussed but poorly understood and has the potential to alter both circulating volume and vascular resistance.
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Sodium transport-related proteins in the mammalian distal nephron - distribution, ontogeny and functional aspects.
TL;DR: The study of mutations of the proteins related with NaCl transport has led to the identification of the molecular causes of inherited human diseases associated with hypo- or hypertension, and the respective sites of an impaired ion transport could be mapped to the kidneys.
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Involvement of glucocorticoids in the reorganization of the amphibian immune system at metamorphosis.
TL;DR: Observations support the hypothesis that loss of larval lymphocytes and changes in lymphocyte function are due to elevated concentrations of glucocorticoids that remove unnecessary lymphocytes to allow for development of immunological tolerance to the new adult-specific antigens that appear as a result of metamorphosis.