Book ChapterDOI
Effects of Fibre Orientation on Electrocardiographic and Mechanical Functions in a Computational Human Biventricular Model
Lei Wang,Zhinuo J. Wang,Ruben Doste,Alfonso Santiago,Xin Zhou,Adria Quintanas,Mariano Vázquez,Blanca Rodriguez +7 more
- pp 351-361
TLDR
In this paper, the authors investigated the effects of the range and transmural gradient of the helix angle on electrocardiogram, pressure-volume loops, circumferential contraction, wall thickening, longitudinal shortening and twist, by using state-of-theart computational human biventricular modelling and simulation.Abstract:
The helix orientated fibres in the ventricular wall modulate the cardiac electromechanical functions. Experimental data of the helix angle through the ventricular wall have been reported from histological and image-based methods, exhibiting large variability. It is, however, still unclear how this variability influences electrocardiographic characteristics and mechanical functions of human hearts, as characterized through computer simulations. This paper investigates the effects of the range and transmural gradient of the helix angle on electrocardiogram, pressure-volume loops, circumferential contraction, wall thickening, longitudinal shortening and twist, by using state-of-the-art computational human biventricular modelling and simulation. Five models of the helix angle are considered based on in vivo diffusion tensor magnetic resonance imaging data. We found that both electrocardiographic and mechanical biomarkers are influenced by these two factors, through the mechanism of regulating the proportion of circumferentially-orientated fibres. With the increase in this proportion, the T-wave amplitude decreases, circumferential contraction and twist increase while longitudinal shortening decreases.read more
References
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Journal ArticleDOI
Image-Based Investigation of Human in Vivo Myofibre Strain
Vicky Y. Wang,Christopher Casta,Yuemin Zhu,Brett R. Cowan,Pierre Croisille,Alistair A. Young,Patrick Clarysse,Martyn P. Nash +7 more
TL;DR: This study provided the first quantitative evidence of homogeneity of ES my ofibre strain using minimally-invasive medical images of the human heart and demonstrated that image-based modelling framework can provide detailed insight to the mechanical behaviour of the myofibres, which may be used as a biomarker for cardiac diseases that affect cardiac mechanics.
Journal ArticleDOI
Human biventricular electromechanical simulations on the progression of electrocardiographic and mechanical abnormalities in post-myocardial infarction.
Zhinuo J. Wang,Alfonso Santiago,Xin Zhou,Lei Wang,Francesca Margara,Francesc Levrero-Florencio,Arka Das,C Kelly,Erica Dall’Armellina,Mariano Vázquez,Blanca Rodriguez +10 more
TL;DR: In this article, a human-based multiscale modelling and simulation framework enables mechanistic investigations into patho-physiological electrophysiological and mechanical behaviour and can serve as testbed to guide the optimization of pharmacological and electrical therapies.
Journal ArticleDOI
Determinants of Left Ventricular Shape Change During Filling
TL;DR: The results suggest that left ventricular shape change is least sensitive to fiber to cross fiber stiffness ratio, and that this will likely limit the practical utility of using shape changes to diagnose changes in myocardial anisotropy.