Journal ArticleDOI
Effects of isolation rearing on startle reactivity, habituation, and prepulse inhibition in male Lewis, Sprague-Dawley, and Fischer F344 rats.
Geoffrey B. Varty,Mark A. Geyer +1 more
TLDR
PPI in Lewis rats is relatively unaffected by either a pharmacological or a developmental manipulation, both of which disrupt PPI in Sprague-Dawley and Fischer F344 rats.Abstract:
This study compared the interaction of strain with isolation rearing on startle reactivity, habituation, and prepulse inhibition (PPI) in male Lewis, Sprague-Dawley, and Fischer F344 rats tested as adults. Lewis and Fischer rats exhibited lower startle reactivity than Sprague-Dawley rats. Lewis rats displayed more rapid habituation than the other strains. Most important, isolation rearing produced deficits in PPI in both Sprague-Dawley and Fischer rats but had no effect in Lewis rats. By contrast, isolation rearing had no effect on startle reactivity or habituation. In a separate study, 0.5 mg/kg apomorphine disrupted PPI in Fischer but not in Lewis rats. Thus, PPI in Lewis rats is relatively unaffected by either a pharmacological or a developmental manipulation, both of which disrupt PPI in Sprague-Dawley and Fischer F344 rats.read more
Citations
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Journal ArticleDOI
Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review.
TL;DR: While the PPI model based on the effects of direct DA agonists is the most well-validated for the identification of known antipsychotic drugs, the isolation rearing model also appears to be sensitive to both typical and atypical antipsychotics, and the 5-HT P PI model is less generally sensitive to antippsychotic medications, but can provide insight into the contribution of serotonergic systems to the actions of newer antipsychosis that act upon multiple receptors.
Journal ArticleDOI
Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges.
TL;DR: The understanding of the neural regulation of PPI has increased tremendously over the past 15 years, and progress has come in "broad strokes", but a number of important details and complex questions remain to be addressed.
Journal ArticleDOI
Behavioural and neurochemical effects of post-weaning social isolation in rodents—Relevance to developmental neuropsychiatric disorders
TL;DR: Unravelling the mechanisms that trigger sequelae will improve knowledge of the aetiology of neurodevelopmental psychiatric disorders, enable identification of longitudinal biomarkers of dysfunction and permit predictive screening for novel compounds with potential antipsychotic efficacy.
Journal ArticleDOI
Animal models of schizophrenia
TL;DR: The review highlights the need to develop more comprehensive animal models that more adequately replicate deficits in negative and cognitive symptoms of schizophrenia, and identifies specific rodent behavioural tasks with translational relevance to specific cognitive domains affected in schizophrenia.
Journal ArticleDOI
Effect of social isolation on stress-related behavioural and neuroendocrine state in the rat.
TL;DR: It is suggested that chronic SI increases emotional reactivity to stress and produces a hyperfunction of the HPA axis in adult rats, particularly in males.
References
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Journal ArticleDOI
Disorders of attention and perception in early schizophrenia.
Andrew McGHIE,James Chapman +1 more
TL;DR: In this article, the authors trace the development of a hypothesis relating to early schizophrenia and outline a proposed method of investigation to test the validity of the theory advanced, which is observed to lie in an impairment of ego functions, particularly in the process of perception.
Journal ArticleDOI
Prestimulus Effects on Human Startle Reflex in Normals and Schizophrenics
TL;DR: When 20 normal subjects were compared to 12 schizophrenic subjects, significant differences in eyeblink response were found for blink amplitude and latency in the 60 msec prestimulus condition, which is consistent with information processing “overload” theories of sensory overstimulation in schizophrenia.
Journal ArticleDOI
Gating and habituation of the startle reflex in schizophrenic patients.
TL;DR: The results indicate that schizophrenic patients have extensive deficits in both intramodal and cross-modal sensorimotor gating and a trend to show acoustic startle habituation deficits.
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Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen antipsychotic drugs
Geoffrey B. Varty,G. A. Higgins +1 more