Journal ArticleDOI
Effects of modulators of the renin-angiotensin-aldosterone system on cough. Losartan Cough Study Group.
Yves Lacourcière,Hans R. Brunner,Richard S. Irwin,Bengt E. Karlberg,Lawrence E. Ramsay,D B Snavely,Tom Dobbins,Elizabeth P. Faison,E B Nelson +8 more
TLDR
The incidence of cough related to the type 1 Ang II receptor antagonist losartan is significantly lower than that observed with lisinopril, and similar to that seen with hydrochlorothiazide in patients with a rechallenged ACE inhibitor cough.Abstract:
ObjectiveTo compare the incidence of cough in patients with a history of angiotensin converting enzyme (ACE) inhibitor-related cough who received losartan [a type 1 angiotensin II (Ang II) receptor antagonist], lisinopril (an ACE inhibitor) or hydrochlorothiazide (a diuretic).DesignAn international,read more
Citations
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Journal ArticleDOI
Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial—the Losartan Heart Failure Survival Study ELITE II
Bertram Pitt,Philip A. Poole-Wilson,Robert Segal,Felipe Martinez,Kenneth Dickstein,A. John Camm,Marvin A. Konstam,Günter A.J. Riegger,George Klinger,James D. Neaton,Divakar Sharma,Balasamy Thiyagarajan +11 more
TL;DR: The ELITE II Losartan Heart Failure Survival Study as discussed by the authors showed an association between the angiotensin II antagonist losartan and an unexpected survival benefit in elderly heart-failure patients, compared with captopril, an ACE inhibitor.
Journal ArticleDOI
Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE)
Bertram Pitt,Robert Segal,Felipe Martinez,Georg Meurers,Alan J. Cowley,Ignatius Thomas,Prakash Deedwania,Dawn E Ney,Duane B. Snavely,Paul I Chang +9 more
TL;DR: Treatment with losartan was associated with an unexpected lower mortality than that found with captopril in older heart-failure patients and there was no difference in renal dysfunction.
Journal ArticleDOI
Guidelines for management of hypertension: report of the fourth working party of the British Hypertension Society, 2004—BHS IV
Bryan Williams,Neil R Poulter,Morris J. Brown,Mark David McGregor Davis,Gordon T. McInnes,John F. Potter,Peter S. Sever,McG Thom S +7 more
TL;DR: Advice on life-style modifications for all people with high blood pressure (BP) and those with borderline or high-normal BP is provided and there are compelling indications and contraindications for specific classes of antihypertensive drugs, and these are specified.
Journal ArticleDOI
The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study.
Françoise Forette,M.L. Seux,Jan A. Staessen,Lutgarde Thijs,M.-R. Babarskiene,Speranta Babeanu,A. Bossini,Robert Fagard,Blas Gil-Extremera,Tovio Laks,Zhanna Kobalava,Cinzia Sarti,Jaakko Tuomilehto,Hannu Vanhanen,John Webster,Yair Yodfat,Willem H. Birkenhäger +16 more
TL;DR: The extended follow-up of Syst-Eur patients reinforces the evidence that blood pressure–lowering therapy initiated with a long-acting dihydropyridine protects against dementia in older patients with systolic hypertension.
Journal ArticleDOI
Angiotensin II receptor antagonists
M Burnier,H. R. Brunner +1 more
TL;DR: The angiotensin-converting enzyme (ACE) inhibitors are a non-specific target for blocking the renin-angioensin enzymatic cascade.
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Cough and angioneurotic edema associated with angiotensin-converting enzyme inhibitor therapy. A review of the literature and pathophysiology.
Zafar H Israili,W D Hall +1 more