Journal ArticleDOI
Effects of plasma irradiation on the wettability and dissolution of compacts of griseofulvin.
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TLDR
Although plasma treatment was found to increase the wettability of griseofulvin it was not found to increasing the dissolution rate as the treatment caused surface fusion of the material.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2004-01-28. It has received 56 citations till now. The article focuses on the topics: Griseofulvin & Dissolution.read more
Citations
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Enhancement of the dissolution rate and oral absorption of a poorly water soluble drug by formation of surfactant-containing microparticles
TL;DR: It is believed that the better wetting characteristics conferred by the hydrophilic surfactant was responsible for the enhanced dissolution rate and absolute oral bioavailability of the model drug.
Journal ArticleDOI
Room temperature ionic liquids and their mixtures: potential pharmaceutical solvents
TL;DR: The solvency of alkyl imidazolium salts (PF(6)(-)Br(-)Cl(-)) for poorly water-soluble model drugs, albendazole and danazol, is reported, indicating their potential application as pharmaceutical solvents/cosolvents.
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Diverse approaches for the enhancement of oral drug bioavailability.
TL;DR: This critical review sought to assess each method aimed at enhancing the oral bioavailability of drugs in terms of the purpose, scientific basis, limitations, commercial application, as well as the areas in which current research efforts are being focused and should be focused in the future.
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Enhanced Oral Bioavailability and Antioxidant Profile of Ellagic Acid by Phospholipids
TL;DR: A novel dietary formulation of EA with phospholipid developed to investigate the effect of this complex on carbon tetrachloride induced liver damage in rats provided better protection to rat liver than free EA at the same dose.
Journal ArticleDOI
Pharmacokinetics of raloxifene in male Wistar-Hannover rats: influence of complexation with hydroxybutenyl-beta-cyclodextrin.
Michael F. Wempe,Vincent J. Wacher,Karen M. Ruble,Michael G. Ramsey,Kevin J. Edgar,Norma Lindsey Buchanan,Charles Michael Buchanan +6 more
TL;DR: Hydroxybutenyl-beta-cyclodextrin (HBenBCD) is a novel solubility enhancer previously demonstrated to increase the oral bioavailability of tamoxifen, letrozole, and itraconazole that significantly increased raloxifene oral bio availability in rats.
References
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Book
Plasma deposition, treatment, and etching of polymers
TL;DR: A.R. Wrobel and M.N. Morosoff as mentioned in this paper, an Introduction to Plasma Polymerization, An Introduction to Plasminarization of Fluorocarbons, and Applications of Plasma Polymers.
Journal ArticleDOI
Correlation between wettability and dissolution rate of pharmaceutical powders
Bernard C. Lippold,Andreas Ohm +1 more
TL;DR: In this paper, the authors calculated the effective surface area and boundary layer thickness of pharmaceutical powders in 2-propanol/water mixtures by taking the corresponding solubilities and diffusion coefficients into account.
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Assessment of wettability and its relationship to the intrinsic dissolution rate of doped phenytoin crystals
TL;DR: In this paper, the surface tension of pure and doped DPH crystals and of the three dopants were assessed using a previously established technique based on the change in sedimentation volume of particles in selected wetting liquid systems.
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Surface characterization and platelet adhesion studies on fluorocarbons prepared by plasma-induced graft polymerization.
TL;DR: In this paper, plasmain-duced grafting polymerization of vinylidene fluoride (VDF) and chlorotrifluoroethylene (CTFE), instead of direct plasma polymerization, was attempted with an aim to improve the substrate blood compatibility.
Journal ArticleDOI
Surface Treatment of meso-Carbon Microbeads by Oxygen Plasma
TL;DR: In this paper, a surface treatment of meso-carbon microbeads was carried out using an oxygen plasma to improve the wettability in aqueous solution, and it was found that the surfaces of the micro-bead were oxidized by oxygen plasma.
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