Journal ArticleDOI
Effects of vitamin B12 on cell proliferation and cellular alkaline phosphatase activity in human bone marrow stromal osteoprogenitor cells and UMR106 osteoblastic cells.
Ghi Su Kim,Chung Hoon Kim,Chung Hoon Kim,Jong Yeon Park,Jong Yeon Park,Kang-Sik Lee,Kang-Sik Lee,Chan-Sik Park,Chan-Sik Park +8 more
TLDR
It is suggested that a suppressed activity of osteoblasts may contribute to osteoporosis and fractures in patients with vitamin B12 deficiency.Abstract:
Pernicious anemia has recently been recognized as one of the risk factors for osteoporosis and bone fractures, but the underlying pathophysiologic mechanism is still unknown. To determine whether vitamin B12 has any direct effect on osteoblasts, we studied the effects of vitamin B12 on the proliferation and alkaline phosphatase activity in human bone marrow stromal osteoprogenitor cells (hBMSC) and UMR106 osteoblastic cells. Vitamin B12 at concentrations as low as 10(-12) mol/L significantly stimulated [3H]-thymidine incorporation in both types of cells, but concentrations higher than 10(-12) mol/L did not produce a greater effect. Vitamin B12 in the concentration range from 10(-12) to 10(-8) mol/L concentration-dependently increased alkaline phosphatase activity in both hBMSC and UMR106 cells. Based on these results, we suggest that a suppressed activity of osteoblasts may contribute to osteoporosis and fractures in patients with vitamin B12 deficiency.read more
Citations
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Journal ArticleDOI
Homocysteine and vitamin B12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people
Rosalie A. M. Dhonukshe-Rutten,Saskia M F Pluijm,Lisette C. P. G. M. de Groot,Paul Lips,Johannes H. Smit,Johannes H. Smit,Wija A. van Staveren +6 more
TL;DR: High Hcy and low vitamin B12 concentrations were significantly associated with low BUA, high markers of bone turnover, and increased fracture risk.
Journal ArticleDOI
Low plasma vitamin B12 is associated with lower BMD: the Framingham Osteoporosis Study.
Katherine L. Tucker,Marian T. Hannan,Ning Qiao,Paul F. Jacques,Jacob Selhub,L. Adrienne Cupples,Douglas P. Kiel +6 more
TL;DR: Men with plasma B12 < 148 pM had significantly lower BMD at the hip, and women at the spine, relative to those with higher B12, and trends were similar for both at all sites.
Journal ArticleDOI
Relation between homocysteine and B-vitamin status indicators and bone mineral density in older Americans
TL;DR: Hcy and vitamin B12 status indicators are associated with BMD in older Americans, and whether this association reflects a causal relation remains unclear and merits further study in light of age-related declines in B 12 status and BMD, and the need for low-risk, easily implemented strategies for osteoporosis prevention.
Journal ArticleDOI
Disorders of cobalamin (vitamin B12) metabolism: emerging concepts in pathophysiology, diagnosis and treatment.
TL;DR: Therapeutic trials with pharmacologic doses of cobalamin are suggested when findings consistent with cobalamine deficiency are present regardless of the results of diagnostic tests.
Journal ArticleDOI
Vitamin B-12 Status Is Associated with Bone Mineral Content and Bone Mineral Density in Frail Elderly Women but Not in Men
Rosalie A. M. Dhonukshe-Rutten,Martine Lips,Nynke de Jong,Marijke J. M. Chin A Paw,Gerrit J Hiddink,Marijke van Dusseldorp,Lisette C. P. G. M. de Groot,Wija A. van Staveren +7 more
TL;DR: It is suggested that vitamin B-12 status is associated with bone health in elderly women and future studies on bone health should take into account a possible role of vitamin B -12 status in different populations.
References
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Journal ArticleDOI
Effect of intermittent cyclical etidronate therapy on bone mass and fracture rate in women with postmenopausal osteoporosis.
TL;DR: Etidronate therapy for postmenopausal osteoporosis results in significant increases in vertebral bone mineral content and, after approximately one year of treatment, a significant decrease in the rate of new vertebral fractures.
Journal ArticleDOI
Differentiation of human bone marrow osteogenic stromal cells in vitro: induction of the osteoblast phenotype by dexamethasone
TL;DR: The results, which demonstrate that Dex conditions the differentiation of human bone marrow osteogenic stromal cells into osteoblast-like cells, support the hypothesis of a permissive effect of glucocorticoids in ensuring an adequate supply of mature osteOBlast populations.
Late effects of gastric bypass for obesity
TL;DR: In this paper, the authors studied 41 patients who had gastric bypass for obesity from 1974-1979 and found that most subjects consumed inadequate diets and many developed iron and/or vitamin B12 deficiencies.
Journal Article
Late effects of gastric bypass for obesity
TL;DR: The procedure was well received by patients and most achieved adequate weight loss, but most subjects consumed inadequate diets and many developed iron and/or vitamin B12 deficiencies, and some also developed abnormal laboratory tests suggesting coexisting osteomalacia.
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Homocysteine levels and the risk of osteoporotic fracture.
Joyce B. J. van Meurs,Rosalie A. M. Dhonukshe-Rutten,Saskia M F Pluijm,Marjolein van der Klift,Robert de Jonge,Jan Lindemans,Lisette C. P. G. M. de Groot,Albert Hofman,Jacqueline C.M. Witteman,Johannes P.T.M. van Leeuwen,Monique M.B. Breteler,Paul Lips,Huibert A. P. Pols,André G. Uitterlinden +13 more