EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as tobacco cigarettes substitute: a prospective 12-month randomized control design study
Pasquale Caponnetto,Davide Campagna,Fabio Cibella,Jaymin B. Morjaria,Massimo Caruso,Cristina Russo,Riccardo Polosa +6 more
Reads0
Chats0
TLDR
In smokers not intending to quit, the use of e-cigarettes, with or without nicotine, decreased cigarette consumption and elicited enduring tobacco abstinence without causing significant side effects.Abstract:
Background: Electronic cigarettes (e-cigarettes) are becoming increasingly popular with smokers worldwide. Users report buying them to help quit smoking, to reduce cigarette consumption, to relieve tobacco withdrawal symptoms, and to continue having a ‘smoking’ experience, but with reduced health risks. Research on e-cigarettes is urgently needed in order to ensure that the decisions of regulators, healthcare providers and consumers are based on science. Methods ECLAT is a prospective 12-month randomized, controlled trial that evaluates smoking reduction/abstinence in 300 smokers not intending to quit experimenting two different nicotine strengths of a popular e-cigarette model (‘Categoria’; Arbi Group Srl, Italy) compared to its non-nicotine choice. GroupA (n=100) received 7.2 mg nicotine cartridges for 12 weeks; GroupB (n=100), a 6-week 7.2 mg nicotine cartridges followed by a further 6-week 5.4 mg nicotine cartridges; GroupC (n=100) received no-nicotine cartridges for 12 weeks. The study consisted of nine visits during which cig/day use and exhaled carbon monoxide (eCO) levels were measured. Smoking reduction and abstinence rates were calculated. Adverse events and product preferences were also reviewed. Results: Declines in cig/day use and eCO levels were observed at each study visits in all three study groups (p,0.001 vs baseline), with no consistent differences among study groups. Smoking reduction was documented in 22.3% and 10.3% at week-12 and week-52 respectively. Complete abstinence from tobacco smoking was documented in 10.7% and 8.7% at week-12 and week-52 respectively. A substantial decrease in adverse events from baseline was observed and withdrawal symptoms were infrequently reported during the study. Participants’ perception and acceptance of the product under investigation was satisfactory. Conclusion: In smokers not intending to quit, the use of e-cigarettes, with or without nicotine, decreased cigarette consumption and elicited enduring tobacco abstinence without causing significant side effects. Trial Registration: ClinicalTrials.gov NCT01164072read more
Citations
More filters
Journal ArticleDOI
The Prevalence of E-Cigarette Use Among Adults in Malaysia:
Jamalludin Ab Rahman,Muhammad Fadhli Mohd Yusoff,Mohamad Haniki Nik Mohamed,Balkish Mahadir Naidu,Kuang Hock Lim,Guat Hiong Tee,Maria Safura Mohamad,Mira Kartiwi,Samsul Draman,Norny Syafinaz Ab Rahman,Tahir Aris +10 more
TL;DR: The overall prevalence of current, ever, former, and dual users of e-cigarettes in Malaysia were 3.2%, and current e-cigarette users were likely to be younger, males, and with higher education level, respectively.
Journal ArticleDOI
Adverse events of smoking cessation treatments (nicotine replacement therapy and non-nicotine prescription medication) and electronic cigarettes in the Food and Drug Administration Adverse Event Reporting System, 2004-2016.
Yumi Motooka,Toshinobu Matsui,Rachel M. Slaton,Ryogo Umetsu,Akiho Fukuda,Misa Naganuma,Shiori Hasegawa,Sayaka Sasaoka,Haruna Hatahira,Kazuhiro Iguchi,Mitsuhiro Nakamura +10 more
TL;DR: It is suggested that an association exists between nicotine-related adverse events and nicotine replacement therapy and healthcare professionals should closely monitor smokers trying to quit nicotine use for the misuse of Nicotine replacement therapy.
Journal ArticleDOI
POINT: Does the Risk of Electronic Cigarettes Exceed Potential Benefits? Yes
Mark V Avdalovic,Susan Murin +1 more
Journal ArticleDOI
Electronic nicotine delivery systems and pregnancy: Recent research on perceptions, cessation, and toxicant delivery.
TL;DR: Overall, with limited evidence of their effectiveness, and concerns about developmental toxicology, the authors do not recommend that pregnant women use ECIGs.
Journal ArticleDOI
Review of electronic cigarettes as tobacco cigarette substitutes: Their potential human health impact
TL;DR: The use of electronic cigarettes (ECs) has been shown to be safer than tobacco cigarette products as the chemical compounds inhaled in the former are believed to be fewer and less toxic than those of the latter.
References
More filters
Journal ArticleDOI
An inventory for measuring clinical anxiety: psychometric properties.
TL;DR: Un nouvel inventaire auto-administre destine a mesurer l'anxiete pathologique, le «Beck Anxiety Cheklist» (BAI) est decrit, evalue et compare au «Hamilton Anxiety Rating Scale» (test avec lequel des correlations moderees sont trouvees).
Treating Tobacco Use and Dependence: 2008 Update
TL;DR: The Panel recognized that variations in study inclusion criteria sometimes were warranted and made recommendations based on evidence, which occurred with topics such as tobacco dependence treatment in specific populations, tailoring interventions, and cost-effectiveness of Tobacco dependence treatment.
Journal ArticleDOI
Measuring nicotine dependence: a review of the Fagerstrom Tolerance Questionnaire.
TL;DR: The findings indicate that the FTQ correlates with other proposed measures of nicotine dependence (carbon monoxide, nicotine, and cotinine levels), and the connection between FTQ scores and withdrawal symptoms is weak.
Journal ArticleDOI
Treating tobacco use and dependence.
TL;DR: This month, the Clinical Practice Guideline (CPG) column reviews the recently published guideline, Treating Tobacco Use and Dependence, available in a quick reference format and more comprehensive clinician's guide that includes detailed information on the methodology and references used to develop the guidelines.