Journal ArticleDOI
Efficient synthesis of mono- and disubstituted 2,3-dihydroquinazolin-4(1H)-ones using KAl(SO4)2·12H2O as a reusable catalyst in water and ethanol
Minoo Dabiri,Peyman Salehi,Somayeh Otokesh,Mostafa Baghbanzadeh,Gholamreza Kozehgary,Ali A. Mohammadi +5 more
TLDR
KAl(SO4)2·12H2O was found to catalyze efficiently a one-pot three-component cyclocondensation of isatoic anhydride and primary amines or ammonia sources such as NH4 2CO3, NH4OAc and NH4Cl with aromatic aldehydes under mild conditions to afford the corresponding mono- and disubstituted 2,3-dihydroquinazolin-4(1H)-ones in good yields as mentioned in this paper.About:
This article is published in Tetrahedron Letters.The article was published on 2005-09-05. It has received 181 citations till now. The article focuses on the topics: Multi-component reaction & Catalysis.read more
Citations
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Journal ArticleDOI
Gallium(III) triflate-catalyzed one-pot selective synthesis of 2,3-dihydroquinazolin-4(1H)-ones and quinazolin-4(3H)-ones
TL;DR: In this article, a series of 2,3-dihydroquinazolin-4(1H)-and quinazolin 4(3H)-ones were synthesized by one-pot reaction using isatoic anhydride, ammonium acetate (or amines), and aldehydes in ethanol or in DMSO under mild conditions.
Journal ArticleDOI
Eco-friendly synthesis of 2,3 -dihydroquinazolin -4 (1H) -ones in ionic liquids or ionic liquid-water without additional catalyst
TL;DR: In this paper, 2,3-Dihydroquinazolin-4(1H)-ones have been synthesized in high to excellent yields through direct cyclocondensation of anthranilamides and aldehydes in ionic liquids (ILs) or one-pot three-component cyclocONDensation of isatoic anhydrides, ammonium acetate and ammonium-acetate in a ionic liquid-water solvent system without the use of any additional catalyst.
Journal ArticleDOI
Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones by Three-Component Coupling of Isatoic Anhydride, Amines, and Aldehydes Catalyzed by Magnetic Fe3O4 Nanoparticles in Water
TL;DR: A simple and efficient protocol for one-pot three-component coupling of isatoic anhydride, amines, and aldehydes in water using magnetically recoverable Fe(3)O(4) nanoparticles is reported.
Journal ArticleDOI
Recent Progress in Three-Component Reactions. An Update
TL;DR: Three-component reactions have emerged as useful methods because the combination of three components to generate new products in a single step is extremely economical, among the multi-component rea... as discussed by the authors.
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1-Methylimidazolium triflouroacetate ([Hmim]TFA): An efficient reusable acidic ionic liquid for the synthesis of 1,8-dioxo-octahydroxanthenes and 1,8-dioxo-decahydroacridines
TL;DR: Bronsted acidic ionic liquid, 1-methylimidazolium triflouroacetate ([Hmim]TFA) catalyzed synthesis of 1,8-dioxo-octahydroxanthenes and 1-8-decahydroacridines in excellent yields and short period of times at 80°C.
References
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Multicomponent Reactions with Isocyanides.
Alexander Dömling,Ivar Ugi +1 more
TL;DR: MCRs and especially MCRs with isocyanides offer many opportunities to attain new reactions and basic structures, however, this requires that the chemist learns the "language" of M CRs, something that this review wishes to stimulate.
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Recent advances in the Biginelli dihydropyrimidine synthesis. New tricks from an old dog.
TL;DR: This Account highlights recent developments in the Biginelli reaction in areas such as solid-phase synthesis, combinatorial chemistry, and natural product synthesis.
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Ueber die künstliche Bildung der Milchsäure und einen neuen, dem Glycocoll homologen Körper;
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Combinatorial synthesis : the design of compound libraries and their application to drug discovery
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Recent advances in isocyanide-based multicomponent chemistry
TL;DR: Multicomponent reactions (MCRs) provide a powerful tool towards the one-pot synthesis of diverse and complex compounds on the one hand and small and 'drug-like' heterocycles on the other hand.