Journal ArticleDOI
Recent advances in isocyanide-based multicomponent chemistry
TLDR
Multicomponent reactions (MCRs) provide a powerful tool towards the one-pot synthesis of diverse and complex compounds on the one hand and small and 'drug-like' heterocycles on the other hand.About:
This article is published in Current Opinion in Chemical Biology.The article was published on 2002-06-01. It has received 444 citations till now.read more
Citations
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Journal ArticleDOI
Recent developments in isocyanide based multicomponent reactions in applied chemistry
Journal ArticleDOI
Chemistry and Biology Of Multicomponent Reactions
TL;DR: This paper presents a new approach to drug design called “combinatorial biosynthesis and drug discovery through nanofiltration”, which combines the efforts of a single investigator with those of a number of other scientists.
Journal ArticleDOI
Asymmetric multicomponent reactions (amcrs): the new frontier
Diego J. Ramón,Miguel Yus +1 more
TL;DR: Asymmetric multicomponent reactions involve the preparation of chiral compounds by the reaction of three or more reagents added simultaneously and has some advantages over classic divergent reaction strategies, such as lower costs, time, and energy, as well as environmentally friendlier aspects.
Journal ArticleDOI
Organic Synthesis “On Water”
Arani Chanda,Valery V. Fokin +1 more
TL;DR: The currently burgeoning field of organic synthesis in aqueous media encompasses a large family of reactions, and water is still not commonly used as a sole solvent for organic synthesis, at least in part because most organic compounds do not dissolve in water to a significant extent.
Journal ArticleDOI
Recent Developments in the Isonitrile‐Based Multicomponent Synthesis of Heterocycles
TL;DR: A review of isocyanide-based multicomponent reactions for heterocycle synthesis can be found in this paper, where the authors advocate a "substrate-design approach" in searching for novel MCRs.
References
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Journal ArticleDOI
Multicomponent Reactions with Isocyanides.
Alexander Dömling,Ivar Ugi +1 more
TL;DR: MCRs and especially MCRs with isocyanides offer many opportunities to attain new reactions and basic structures, however, this requires that the chemist learns the "language" of M CRs, something that this review wishes to stimulate.
Journal ArticleDOI
Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria
Frank Schlünzen,Raz Zarivach,J. Harms,Anat Bashan,Ante Tocilj,Renate Albrecht,Ada Yonath,Francois Franceschi +7 more
TL;DR: The details of antibiotic interactions with the components of their binding sites are reported and the importance of putative Mg+2 ions for the binding of some drugs is shown to facilitate rational drug design.
Book
The Logic of Chemical Synthesis
E. J. Corey,Xue-Min Cheng +1 more
TL;DR: A general approach to the analysis of complex synthetic problems: the basis for retrosynthetic analysis transform-based strategies structure-based and topological strategies stereochemical strategies functional group based and other strategies concurrent use of several strategies.
Journal ArticleDOI
Pairwise use of complexity-generating reactions in diversity-oriented organic synthesis.
TL;DR: Two pairs of complexity-generating reactions with an essential product-substrate relationship along a synthetic pathway are demonstrated, illustrating a key element in a planning algorithm for diversity-oriented synthesis.
Journal ArticleDOI
Isonitrile, II. Reaktion von Isonitrilen mit Carbonylverbindungen, Aminen und Stickstoffwasserstoffsäure
Ivar Ugi,Cornelius Steinbrückner +1 more
TL;DR: In this article, der Chemismus der Reaktion und ihr Anwendungsbereich werden diskutiert, i.e., der chemismus of reaction and i. e. g.