Journal ArticleDOI
Electron microscopical studies on rat brain neurons. Localization of acid phosphatase and mode of formation of lipofuscin bodies.
TLDR
The evidence suggested that acid phosphatase was continuously transported to the lipofuscin bodies throughout the life-span of the cells.About:
This article is published in Journal of Ultrastructure Research.The article was published on 1972-01-01. It has received 134 citations till now. The article focuses on the topics: Residual body & Lipofuscin.read more
Citations
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Lipofuscin: mechanisms of age-related accumulation and influence on cell function
Ulf T. Brunk,Alexei Terman +1 more
TL;DR: The accumulation of lipofuscin within postmitotic cells is a recognized hallmark of aging occuring with a rate inversely related to longevity as mentioned in this paper, whereas proliferative cells efficiently dilute it during division.
Journal ArticleDOI
Oxidative stress: Free radical production in neural degeneration
TL;DR: The oxidative stress theory of neurodegeneration, on excitotoxin-induced cell damage and on impairment of mitochondrial function are focused on as three major noxae being the most likely causes of cell death either independently or in connection with each other.
Journal ArticleDOI
Biochemical basis of lipofuscin, ceroid, and age pigment-like fluorophores.
TL;DR: This review discusses several critical controversies in this field and lays special emphasis on the cellular and biochemical reactions related to the formation mechanisms of lipofuscin, ceroid, advanced glycation end-products (AGEs), and age pigment like fluorophores (APFs).
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Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates.
TL;DR: An overview of recent developments in ischemic neuronal death is provided, the cascade of the primate neuronal death with particular attentions to the cysteine proteases is presented, and selective cathepsin inhibitors as a novel neuroprotectant are indicated.
Journal ArticleDOI
Lipofuscin: formation, distribution, and metabolic consequences
TL;DR: This review highlights the current knowledge of the formation, distribution, and effects of lipofuscin in mammalian cells and investigates the role of mitochondria repair systems and the functionality and effectiveness of the lysosomes.
References
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Book
Lysosomes in biology and pathology
TL;DR: By reading this book as soon as possible, you can renew the situation to get the inspirations and will lead you to always think more and more.
Journal ArticleDOI
Lysosome function in the regulation of the secretory process in cells of the anterior pituitary gland.
TL;DR: In secretory cells, lysosomes function in the regulation of the secretory process by providing a mechanism which takes care of overproduction of secretory products.
Journal ArticleDOI
Specific granules in atrial muscle cells.
TL;DR: Atrial granules are larger and more numerous in smaller species (rat, mouse), and generally smaller and less numerous in larger mammals (dog, cat, human); they are absent from the atrial fibers of very young fetuses but are present in those of newborn animals.
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Human hepatocellular pigments and lysosomes.
E. Essner,A.B. Novikoff +1 more
TL;DR: These findings provide evidence for the suggestion that the pericanalicular dense bodies are the lysosomes of the hepatic cell, including a role in the intracellular transport of bile.