Electrophysiologic characteristics andimplications of induced ventricular fibrillationin symptomatic patients with brugada syndrome
Munetake Kanda,Wataru Shimizu,Kiyotaka Matsuo,Noritoshi Nagaya,Atsushi Taguchi,Kazuhiro Suyama,Takashi Kurita,Naohiko Aihara,Shiro Kamakura +8 more
TLDR
The data suggest that induction of VF by PVS depends on the severity ofdepolarization abnormalities but does not predict the recurrence of cardiac events in symptomatic Brugada syndrome, indicating that both depolarization and repolarization irregularities are important in the development of Vf.About:
This article is published in Journal of the American College of Cardiology.The article was published on 2002-06-05 and is currently open access. It has received 129 citations till now. The article focuses on the topics: Brugada syndrome & Ventricular fibrillation.read more
Citations
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Journal ArticleDOI
Brugada Syndrome: Report of the Second Consensus Conference Endorsed by the Heart Rhythm Society and the European Heart Rhythm Association
Charles Antzelevitch,Pedro Brugada,Martin Borggrefe,Josep Brugada,Ramon Brugada,Domenico Corrado,Ihor Gussak,Herve LeMarec,Koonlawee Nademanee,Andrés Ricardo Pérez Riera,Wataru Shimizu,Eric Schulze-Bahr,H.L. (Hanno) Tan,Arthur A.M. Wilde +13 more
TL;DR: The present report elaborates further on the diagnostic criteria and examines risk stratification schemes and device and pharmacological approaches to therapy on the basis of the available clinical and basic science data.
Journal ArticleDOI
Fragmented QRS as a Marker of Conduction Abnormality and a Predictor of Prognosis of Brugada Syndrome
Hiroshi Morita,Kengo F. Kusano,Daiji Miura,Satoshi Nagase,Kazufumi Nakamura,Shiho T. Morita,Tohru Ohe,Douglas P. Zipes,Jiashin Wu +8 more
TL;DR: In this paper, the authors found that f-QRS could indicate a substrate for VF and might predict a high risk of VF for patients with Brugada syndrome (BS).
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Outcome After Implantation of a Cardioverter-Defibrillator in Patients With Brugada Syndrome A Multicenter Study
Frederic Sacher,Vincent Probst,Yoshito Iesaka,Peggy Jacon,Julien Laborderie,Frederique Mizon-Gerard,Philippe Mabo,Sylvain Reuter,Dominique Lamaison,Yoshihide Takahashi,Mark D O'Neill,Stéphane Garrigue,Bertrand Pierre,Pierre Jaïs,Jean-Luc Pasquié,Mélèze Hocini,Michèle Salvador-Mazenq,Akihiko Nogami,Alain Amiel,Pascal Defaye,Pierre Bordachar,Serge Boveda,Philippe Maury,Didier Klug,Dominique Babuty,Michel Haïssaguerre,Jacques Mansourati,Jacques Clementy,Hervé Le Marec +28 more
TL;DR: Optimal implantable cardioverter-defibrillator programming and follow-up dramatically reduce inappropriate shock in patients with Brugada syndrome, but lead failure remains a major problem in this population.
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Pathophysiological mechanisms of Brugada syndrome: depolarization disorder, repolarization disorder, or more?
TL;DR: Clinical and experimental studies are reviewed as they provide evidence to support or disprove the two hypotheses on the mechanism of Brugada syndrome that currently receive the widest support: (1) nonuniform abbreviation of right ventricular epicardial action potentials ("repolarization disorder"), (2) conduction delay in theright ventricular outflow tract ("depolarization Disorder").
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Risk Stratification of Individuals with the Brugada Electrocardiogram: A Meta-Analysis
TL;DR: A meta‐analysis of prognostic studies of patients with a Brugada ECG to assess predictors of events found that the prognostic value of an ECG has been overestimated in the past and underestimated in the future.
References
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Journal ArticleDOI
Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report.
Pedro Brugada,Josep Brugada +1 more
TL;DR: Common clinical and ECG features define a distinct syndrome in this group of patients with recurrent episodes of aborted sudden death unexplainable by currently known diseases, not explainable by electrolyte disturbances, ischemia or structural heart disease.
Journal ArticleDOI
Genetic basis and molecular mechanism for idiopathic ventricular fibrillation
Qiuyun Chen,Glenn E. Kirsch,Danmei Zhang,Ramon Brugada,Josep Brugada,Pedro Brugada,Domenico Potenza,Angel Moya,Martin Borggrefe,Günter Breithardt,Rocio Ortiz-Lopez,Zhiqing Wang,Charles Antzelevitch,Richard E. O'Brien,Eric Schulze-Bahr,Mark T. Keating,Jeffrey A. Towbin,Qing Wang +17 more
TL;DR: It is shown that sodium channels with the missense mutation recover from inactivation more rapidly than normal and that the frameshift mutation causes the sodium channel to be non-functional.
Journal ArticleDOI
Cellular Basis for the Brugada Syndrome and Other Mechanisms of Arrhythmogenesis Associated With ST-Segment Elevation
Gan-Xin Yan,Charles Antzelevitch +1 more
TL;DR: Depression or loss of the action potential dome in RV epicardium creates a transmural voltage gradient that may be responsible for the ST-segment elevation observed in the Brugada syndrome and other syndromes exhibiting similar ECG manifestations.
Journal ArticleDOI
Sodium Channel Blockers Identify Risk for Sudden Death in Patients With ST-Segment Elevation and Right Bundle Branch Block but Structurally Normal Hearts
Ramon Brugada,Josep Brugada,Charles Antzelevitch,Glenn E. Kirsch,Domenico Potenza,Jeffrey A. Towbin,Pedro Brugada +6 more
TL;DR: A similar incidence of potentially lethal arrhythmias in patients displaying transient versus persistent ST-segment elevation and right bundle branch block is demonstrated, as well as the effectiveness of sodium channel blockers to unmask the syndrome and, thus, identify patients at risk.
Journal ArticleDOI
Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome
Toshihisa Miyazaki,Hideo Mitamura,Shunichiro Miyoshi,Kyoko Soejima,Yoshifusa Aizawa,Satoshi Ogawa +5 more
TL;DR: ST segment elevation in patients with Brugada syndrome was augmented by selective stimulation of alpha-adrenoceptors or muscarinic receptors or by class IA drugs but was mitigated by beta- adrenoceptor stimulation or alpha-adsenoceptor blockade.
Related Papers (5)
Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report.
Pedro Brugada,Josep Brugada +1 more