Journal ArticleDOI
Embryonic death in mouse due to lead exposure.
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TLDR
Lead treatment was found to reduce significantly the incidence of pregnancies and to increase the postimplantation loss in the pregnant females.Abstract:
Female mice which displayed a vaginal plug after mating were given a diet containing 0, 0.125, 0.250, 0.500% of lead as lead acetate and were dissected 16 to 18 days later. Lead treatment was found to reduce significantly the incidence of pregnancies and to increase the postimplantation loss in the pregnant females.read more
Citations
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Journal ArticleDOI
Metal-induced developmental toxicity in mammals: a review.
TL;DR: Summary of the toxic effects that excesses of certain metals may cause on mammalian development and the therapeutic use of chelating agents in the prevention of metal-induced developmental toxicity.
Journal ArticleDOI
Chronic low-level lead toxicity in the rat. III. An integrated assessment of long-term toxicity with special reference to the kidney
Bruce A. Fowler,Bruce A. Fowler,Bruce A. Fowler,Carole A. Kimmel,Carole A. Kimmel,Carole A. Kimmel,James S. Woods,James S. Woods,James S. Woods,Ernest E. McConnell,Ernest E. McConnell,Ernest E. McConnell,Lester D. Grant,Lester D. Grant,Lester D. Grant +14 more
TL;DR: Male and female rats whose mothers had been exposed to Pb before and during pregnancy and lactation at exposure levels of 0, 0.5, 5, 25, 50, and 250 ppm Pb as Pb-acetate in drinking water were continued on the respective regimens for 6 or 9 months, finding effects were more marked after 9 months exposure.
Journal ArticleDOI
Toxicity, mutagenicity and teratogenicity of lead
TL;DR: The data on man are controversial because lead is almost never the only potentially mutagenic agent to which people are exposed in an industrial environment, and the efficiency of lead in causing such aberrations appears low compared with that of other mutagenics so that genetic effects of lead do not appear of primary concern for human health.
Journal ArticleDOI
Chronic low-level lead toxicity in the rat. I. Maternal toxicity and perinatal effects.
Carole A. Kimmel,Carole A. Kimmel,Carole A. Kimmel,Lester D. Grant,Lester D. Grant,Lester D. Grant,Carol S. Sloan,Carol S. Sloan,Carol S. Sloan,Beth C. Gladen,Beth C. Gladen,Beth C. Gladen +11 more
TL;DR: In this paper, the first in a series of studies on the chronic exposure of rats to lead (Pb) is reported, where weanling females were provided semipurified diets containing no detectable Pb, and drinking water containing 0, 0.5, 5, 25, 50, or 250 ppm Pb (as Pb-acetate).
Journal ArticleDOI
Potential human developmental toxicants and the role of animal testing in their identification and characterization.
James L. Schardein,Kit A. Keller +1 more
TL;DR: In general, animal developmental toxicity data closely paralleled human outcomes, and while humans in most cases were more sensitive than animals, the data support the concept that, imperfections aside, studies in animals serve a vital role in the hazard identification process.
References
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Journal ArticleDOI
Toxic Effects of Trace Elements on the Reproduction of Mice and Rats
TL;DR: This method provides fairly rapid estimates of innate toxicities of trace elements in doses tolerable for growth and survival, and in rats, lead was very toxic, and titanium and nickel moderately toxic, resulting in many early deaths and runts.
Journal ArticleDOI
Zirconium, niobium, antimony, vanadium and lead in rats: life term studies.
TL;DR: In rats given antimony, nonfasting serum glucose levels were lower than fasting, an unusual finding, and increased incidences of glycosuria occurred in the zirconium, niobium and lead groups.
Journal Article
Effects of sublethal doses of certain minerals on pregnant ewes and fetal development.
TL;DR: Seven groups of 4 yearling ewes each were fed salts of antimony, arsenic, bismuth, copper, lead, tellurium, and zinc, these minerals were selected since they may occur in relatively great amounts in certain rangeland area in western U.S.
Journal ArticleDOI
The specificity of the teratogenic effect of lead in the golden hamster.
Vergil H. Ferm,D.W. Ferm +1 more
Journal ArticleDOI
The increasing use of lead as an abortifacient: a series of thirty cases of plumbism.
TL;DR: If the cavity is large and the surface irregular, due to hypertrophied and necrotic decidua, the patient's safety can only be ensured by its complete removal, and there is no doubt that this is most efficiently done by the use of a suitable curette.
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