Journal ArticleDOI
Enhancement of the anti-Salmonella immune response in CD154-deficient mice by an attenuated, IFN-γ-expressing, strain of Salmonella enterica serovar Typhimurium
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TLDR
It is demonstrated that GIDIFN has immunopotentiating effects on the host's immune response and provided direct evidence for the utility of IFN-γ-expressing attenuated Salmonella in enhancement of immune responsiveness in immunodeficient hosts.About:
This article is published in Microbial Pathogenesis.The article was published on 2012-06-01. It has received 6 citations till now. The article focuses on the topics: Salmonella enterica & Salmonella.read more
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Journal ArticleDOI
CD40 ligand deficiency causes functional defects of peripheral neutrophils that are improved by exogenous IFN-γ
Otavio Cabral-Marques,Tabata Takahashi França,Ashraf Al-Sbiei,Lena F. Schimke,Taj Ali Khan,Taj Ali Khan,Claudia Feriotti,Tania Alves da Costa,Osvaldo Reis Junior,Cristina Worm Weber,Janaíra Fernandes Ferreira,Fabiola Scancetti Tavares,Cláudia França Cavalcante Valente,Regina Sumiko Watanabe Di Gesu,Asif Iqbal,Gabriela Riemekasten,Gustavo P. Amarante-Mendes,José Alexandre Marzagão Barbuto,Beatriz Tavares Costa-Carvalho,Paulo Vitor Soeiro Pereira,Paulo Vitor Soeiro Pereira,Maria J. Fernandez-Cabezudo,Vera Lúcia Garcia Calich,Luigi D. Notarangelo,Troy R. Torgerson,Basel K. al-Ramadi,Hans D. Ochs,Antonio Condino-Neto +27 more
TL;DR: The data suggest a nonredundant role of CD40L‐CD40 interaction in neutrophil development and function that could be improved in vitro by rhIFN‐&ggr;, indicating a potential novel therapeutic application for this cytokine.
Journal ArticleDOI
Induction of Hypergammaglobulinemia and Autoantibodies by Salmonella Infection in MyD88-Deficient Mice.
Jincy M. Issac,Yassir A. Mohamed,Ghada Bashir,Ashraf Al-Sbiei,Walter Conca,Taj Ali Khan,Asif Iqbal,Gabriela Riemekasten,Katja Bieber,Ralf Ludwig,Otavio Cabral-Marques,Maria J. Fernandez-Cabezudo,Basel K. al-Ramadi +12 more
TL;DR: It is shown that MyD 88−/− mice are unable to eliminate attenuated Salmonella enterica serovar Typhimurium, even when challenged with a low-dose inoculum, and dysregulation of the immune response in the absence of MyD88 is pathogen-dependent, highlighting potentially important genotype–environmental factor correlations.
Patent
Campylobacter immunogenic compositions and uses thereof
TL;DR: In this article, a method for using immunogenic compositions against Campylobacter and methods for using the immunogenic composition to generate an immune response against campylobacteria and/or reduce intestinal colonisation by the bacteria is presented.
Journal ArticleDOI
Cinobufagin enhances the protective efficacy of formalin-inactivated Salmonella typhimurium vaccine through Th1 immune response.
Shuai-Cheng Wu,Peng-Fei Yi,Xun Guo,Li-Yan Zhang,Dao-Xiu Xu,Yun-Xing Fu,Zhen-Qiang Cui,Hai-Qing Shen,Xu-Bin Wei,Ben-Dong Fu +9 more
TL;DR: In vivo protection studies showed that CBG significantly decreased the bacterial burdens in the spleen and prolonged the survival time of FIST-immunized mice challenged with live Salmonella typhimurium, promoting the Th1 immune response.
References
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Journal ArticleDOI
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5.
Fumitaka Hayashi,Kelly D. Smith,Adrian Ozinsky,Thomas R. Hawn,Thomas R. Hawn,Eugene C. Yi,David R. Goodlett,Jimmy K. Eng,Shizuo Akira,David M. Underhill,Alan Aderem +10 more
TL;DR: It is reported that mammalian TLR5 recognizes bacterial flagellin from both Gram-positive and Gram-negative bacteria, and that activation of the receptor mobilizes the nuclear factor NF-κB and stimulates tumour necrosis factor-α production, and the data suggest thatTLR5, a member of the evolutionarily conserved Toll-like receptor family, has evolved to permit mammals specifically to detect flageLLated bacterial pathogens.
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Alternative Activation of Macrophages: An Immunologic Functional Perspective
TL;DR: The cellular sources of these cytokines, receptor signaling pathways, and induced markers and gene signatures are reviewed and the concept of macrophage activation in the context of the immune response is revisit.
Journal ArticleDOI
Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines.
TL;DR: The use of a tetracycline-resistance transposon, Tn10 (refs 5, 6), inserted in gene aroA to produce non-reverting, aromatic-requiring derivatives of virulent S. typhimurium strains were virtually non-virulent; their use as live vaccines conferred excellent protection against challenge with a virulent strain.
Journal ArticleDOI
CD40 and CD154 in cell-mediated immunity.
TL;DR: The role of the CD40-CD154 system is focused on in the regulation of many newly discovered functions important in inflammation and cell-mediated immunity.
Journal ArticleDOI
Visualization of Specific B and T Lymphocyte Interactions in the Lymph Node
Paul Garside,Elizabeth Ingulli,Rebecca Merica,Julia G. Johnson,Randolph J. Noelle,Marc K. Jenkins +5 more
TL;DR: These results provide visual documentation of cognate T-B cell interactions and localize them to the follicular border.