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Calman A. MacLennan
Researcher at Bill & Melinda Gates Foundation
Publications - 149
Citations - 6589
Calman A. MacLennan is an academic researcher from Bill & Melinda Gates Foundation. The author has contributed to research in topics: Salmonella & Salmonella enterica. The author has an hindex of 40, co-authored 136 publications receiving 5371 citations. Previous affiliations of Calman A. MacLennan include Malawi-Liverpool-Wellcome Trust Clinical Research Programme & University of Malawi.
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Journal ArticleDOI
Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype
Robert A. Kingsley,Chisomo L. Msefula,Nicholas R. Thomson,Samuel Kariuki,Samuel Kariuki,Kathryn E. Holt,Melita A. Gordon,David Harris,Louise Clarke,Sally Whitehead,Vartul Sangal,Kevin Marsh,Mark Achtman,Malcolm E. Molyneux,Martin Cormican,Julian Parkhill,Calman A. MacLennan,Robert S. Heyderman,Gordon Dougan +18 more
TL;DR: Genome analysis of other epidemic ST313 isolates from Malawi and Kenya provided evidence for microevolution and clonal replacement in the field, including evidence of genome degradation, including pseudogene formation and chromosomal deletions, when compared with other S. Typhimurium genome sequences.
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Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events
Vanessa K. Wong,Vanessa K. Wong,Stephen Baker,Stephen Baker,Stephen Baker,Derek Pickard,Julian Parkhill,Andrew J. Page,Nicholas A. Feasey,Robert A. Kingsley,Robert A. Kingsley,Nicholas R. Thomson,Nicholas R. Thomson,Jacqueline A. Keane,François-Xavier Weill,David J. Edwards,Jane Hawkey,Simon R. Harris,Alison E. Mather,Amy K. Cain,James Hadfield,Peter J. Hart,Nga Tran Vu Thieu,Elizabeth J. Klemm,Dafni A. Glinos,Robert F. Breiman,Robert F. Breiman,Robert F. Breiman,Conall H. Watson,Samuel Kariuki,Samuel Kariuki,Melita A. Gordon,Robert S. Heyderman,Chinyere K. Okoro,Jan Jacobs,Jan Jacobs,Octavie Lunguya,W. John Edmunds,Chisomo L. Msefula,José A. Chabalgoity,Mike Kama,Kylie Jenkins,Shanta Dutta,Florian Marks,Josefina Campos,Corinne N. Thompson,Corinne N. Thompson,Stephen K. Obaro,Calman A. MacLennan,Calman A. MacLennan,Calman A. MacLennan,Christiane Dolecek,Karen H. Keddy,Anthony M. Smith,Christopher M. Parry,Christopher M. Parry,Abhilasha Karkey,E. Kim Mulholland,James Campbell,James Campbell,Sabina Dongol,Buddha Basnyat,Muriel Dufour,Don Bandaranayake,Take Toleafoa Naseri,Shalini Singh,Mochammad Hatta,Paul N. Newton,Paul N. Newton,Robert S. Onsare,Lupeoletalalei Isaia,David A. B. Dance,David A. B. Dance,Viengmon Davong,Guy E. Thwaites,Guy E. Thwaites,Lalith Wijedoru,John A. Crump,Elizabeth de Pinna,Satheesh Nair,Eric J. Nilles,Duy Pham Thanh,Paul Turner,Paul Turner,Paul Turner,Sona Soeng,Mary Valcanis,Joan Powling,Karolina Dimovski,Geoff Hogg,Jeremy Farrar,Jeremy Farrar,Kathryn E. Holt,Gordon Dougan +93 more
TL;DR: This whole-genome sequence analysis of Salmonella enterica serovar Typhi identifies a single dominant MDR lineage, H58, that has emerged and spread throughout Asia and Africa over the last 30 years, and identifies numerous transmissions of H58.
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Morbidity and mortality due to shigella and enterotoxigenic Escherichia coli diarrhoea: the Global Burden of Disease Study 1990-2016.
Ibrahim A Khalil,Christopher Troeger,Brigette F. Blacker,Puja C Rao,Alexandria Brown,Deborah Atherly,Thomas G Brewer,Cyril Engmann,Cyril Engmann,Eric R. Houpt,Gagandeep Kang,Karen L. Kotloff,Myron M. Levine,Stephen P. Luby,Calman A. MacLennan,William Pan,William Pan,Patricia B Pavlinac,James A Platts-Mills,Firdausi Qadri,Mark S. Riddle,Edward T. Ryan,David A Shoultz,A. Duncan Steele,Judd L. Walson,John W. Sanders,Ali H. Mokdad,Christopher J L Murray,Simon I. Hay,Simon I. Hay,Robert Reiner +30 more
TL;DR: The global burden of shigella and ETEC diarrhoea according to age, sex, geography, and year from 1990 to 2016 is analyzed to assess the health burden of bacterial diarrhoeal pathogens globally.
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Intracontinental spread of human invasive Salmonella Typhimurium pathovariants in sub-Saharan Africa
Chinyere K. Okoro,Robert A. Kingsley,Thomas R. Connor,Simon R. Harris,Christopher M. Parry,Christopher M. Parry,Manar Najim Al-Mashhadani,Samuel Kariuki,Chisomo L. Msefula,Melita A. Gordon,Elizabeth de Pinna,John Wain,John Wain,Robert S. Heyderman,Robert S. Heyderman,Stephen K Obaro,Pedro L. Alonso,Pedro L. Alonso,Inacio Mandomando,Calman A. MacLennan,Calman A. MacLennan,Milagritos D. Tapia,Myron M. Levine,Sharon M. Tennant,Julian Parkhill,Gordon Dougan +25 more
TL;DR: It is suggested that iNTS disease is in part an epidemic in sub-Saharan Africa caused by highly related Salmonella Typhimurium lineages that may have occupied new niches associated with a compromised human population and antibiotic treatment.
Journal ArticleDOI
The neglected role of antibody in protection against bacteremia caused by nontyphoidal strains of Salmonella in African children
Calman A. MacLennan,Esther N. Gondwe,Chisomo L. Msefula,Robert A. Kingsley,Nicholas R. Thomson,Sarah A. White,Margaret Goodall,Derek Pickard,Stephen M. Graham,Gordon Dougan,C. Anthony Hart,Malcolm E. Molyneux,Mark T. Drayson +12 more
TL;DR: It is concluded that Salmonella-specific antibody that overcomes the complement resistance of NTS develops by 2 years of life in Malawian children, suggesting that antibody protects against NTS bacteremia and support the development of vaccines against NTS that induce protective antibody.