Enhancing the bioavailability of resveratrol by combining it with piperine.
Jeremy J. Johnson,Minakshi Nihal,Imtiaz A. Siddiqui,Cameron O. Scarlett,Howard H. Bailey,Hasan Mukhtar,Nihal Ahmad +6 more
TLDR
Piperine significantly improves the in vivo bioavailability of resveratrol through inhibiting its glucuronidation, thereby slowing its elimination and further detailed research is needed to study the mechanism of improved bioavailability via its combination with piperine.Abstract:
Scope Resveratrol (3,5,4'-trihydroxystilbene) is a phytoalexin shown to possess a multitude of health-promoting properties in pre-clinical studies. However, the poor in vivo bioavailability of resveratrol due to its rapid metabolism is being considered as a major obstacle in translating its effects in humans. In this study, we examined the hypothesis that piperine will enhance the pharmacokinetic parameters of resveratrol via inhibiting its glucuronidation, thereby slowing its elimination. Methods and results Employing a standardized LC/MS assay, we determined the effect of piperine co-administration with resveratrol on serum levels resveratrol and resveratrol-3-O-β-D-glucuronide in C57BL mice. Mice were administered resveratrol (100 mg/kg; oral gavage) or resveratrol (100 mg/kg; oral gavage)+piperine (10 mg/kg; oral gavage), and the serum levels of resveratrol and resveratrol-3-O-β-D-glucuronide were analyzed at different times. We found that the degree of exposure (i.e. AUC) to resveratrol was enhanced to 229% and the maximum serum concentration (C(max)) was increased to 1544% with the addition of piperine. Conclusion Our study demonstrated that piperine significantly improves the in vivo bioavailability of resveratrol. However, further detailed research is needed to study the mechanism of improved bioavailability of resveratrol via its combination with piperine as well as its effect on resveratrol metabolism.read more
Citations
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Absorption and Metabolism of Piceatannol in Rats
Yuko Setoguchi,Yukihiro Oritani,Ryouichi Ito,Hiroyuki Inagaki,Hiroko Maruki-Uchida,Takashi Ichiyanagi,Tatsuhiko Ito +6 more
TL;DR: The plasma concentrations of piceatannol, resveratrol, and their respective metabolites following their intragastric administration were determined and the area under the plasma concentration curves (AUC) and metabolic pathway of p iceatannl were compared with those of resver atrol.
Journal ArticleDOI
The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer's disease pathology: From antioxidant to epigenetic therapy
Christian Griñán-Ferré,Aina Bellver-Sanchis,Vanessa Izquierdo,Rubén Corpas,Joan Roig-Soriano,Miguel Chillón,Cristina Andres-Lacueva,Milán Somogyvári,Csaba Sőti,Coral Sanfeliu,Mercè Pallàs +10 more
TL;DR: A comprehensive overview of the main mechanisms of action of Resveratrol in different experimental models, including clinical trials and discuss how the interconnection of these molecular events could explain the neuroprotective effects induced by RV as discussed by the authors.
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Cardiovascular Protective Effects and Clinical Applications of Resveratrol.
Sanghyun Cho,Kyung Namkoong,Minji Shin,Jueun Park,Eunyeong Yang,Jinsoo Ihm,Vu Thi Thu,Vu Thi Thu,Hyoung Kyu Kim,Jin Han +9 more
TL;DR: This article reviews recently reported basic research results that describe the beneficial effects of resveratrol in an attempt to condense the evidence observed in clinical trials and provide support for the future development of novel clinical therapeutics in patients with cardiovascular diseases.
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Resveratrol Biosynthesis: Plant Metabolic Engineering for Nutritional Improvement of Food
TL;DR: This review focuses on the latest findings regarding on resveratrol bioproduction and its effects on the prevention of the major pathological conditions in man.
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Resveratrol is a promising agent for colorectal cancer prevention and treatment: focus on molecular mechanisms
TL;DR: The aim of the current review is to depict the role of resveratrol in treatment of CRC in a molecular manner.
References
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Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers
TL;DR: The study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects.
Journal ArticleDOI
High absorption but very low bioavailability of oral resveratrol in humans
TL;DR: The dietary polyphenol resveratrol has been shown to have chemopreventive activity against cardiovascular disease and a variety of cancers in model systems, but it is not clear whether the drug reaches the proposed sites of action in vivo after oral ingestion, especially in humans.
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PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel
TL;DR: The PKSolver provided pharmacokinetic researchers with a fast and easy-to-use tool for routine and basic PK and PD data analysis with a more user-friendly interface and its output could be generated in Microsoft Word in the form of an integrated report.