Enhancing the bioavailability of resveratrol by combining it with piperine.
Jeremy J. Johnson,Minakshi Nihal,Imtiaz A. Siddiqui,Cameron O. Scarlett,Howard H. Bailey,Hasan Mukhtar,Nihal Ahmad +6 more
TLDR
Piperine significantly improves the in vivo bioavailability of resveratrol through inhibiting its glucuronidation, thereby slowing its elimination and further detailed research is needed to study the mechanism of improved bioavailability via its combination with piperine.Abstract:
Scope Resveratrol (3,5,4'-trihydroxystilbene) is a phytoalexin shown to possess a multitude of health-promoting properties in pre-clinical studies. However, the poor in vivo bioavailability of resveratrol due to its rapid metabolism is being considered as a major obstacle in translating its effects in humans. In this study, we examined the hypothesis that piperine will enhance the pharmacokinetic parameters of resveratrol via inhibiting its glucuronidation, thereby slowing its elimination. Methods and results Employing a standardized LC/MS assay, we determined the effect of piperine co-administration with resveratrol on serum levels resveratrol and resveratrol-3-O-β-D-glucuronide in C57BL mice. Mice were administered resveratrol (100 mg/kg; oral gavage) or resveratrol (100 mg/kg; oral gavage)+piperine (10 mg/kg; oral gavage), and the serum levels of resveratrol and resveratrol-3-O-β-D-glucuronide were analyzed at different times. We found that the degree of exposure (i.e. AUC) to resveratrol was enhanced to 229% and the maximum serum concentration (C(max)) was increased to 1544% with the addition of piperine. Conclusion Our study demonstrated that piperine significantly improves the in vivo bioavailability of resveratrol. However, further detailed research is needed to study the mechanism of improved bioavailability of resveratrol via its combination with piperine as well as its effect on resveratrol metabolism.read more
Citations
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Effect of wine polyphenol resveratrol on the contractions elicited electrically or by norepinephrine in the rat portal vein.
Dragana Protić,Bojana B. Beleslin-Cokic,Radmila Novakovic,Vladimir Kanjuh,Helmut Heinle,Radisav Scepanovic,Ljiljana Gojkovic-Bukarica +6 more
TL;DR: It is shown that BKCa channels partly mediate the inhibitory effect of resveratrol on the neurogenic contractions of RPV, and the smooth muscle Ca2+ channels and/or Ca2- mobilizing through cells might be involved in the effects of resversing on the contractility ofRPV.
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Neuroprotective Effects of Resveratrol in In vivo and In vitro Experimental Models of Parkinson’s Disease: a Systematic Review
M. G. dos Santos,Lucia Emanueli Schimith,Corinne André-Miral,Ana Luiza Muccillo-Baisch,Bruno Dutra Arbo,Mariana Appel Hort +5 more
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High light bio-fortification stimulates de novo synthesis of resveratrol in Diplotaxis tenuifolia (wild rocket) micro-greens
TL;DR: The use of high light resulted in successful bio-fortification of wild rocket micro-greens, evidenced by the accumulation of previously undocumented polyphenols (such as resveratrol, catechin and epicatechin) and improved anti-oxidant capacity.
Book ChapterDOI
Pathways Linked to Cancer Chemoresistance and Their Targeting by Nutraceuticals
TL;DR: The results demonstrate that nutraceuticals may be developed as clinically useful anticancer chemosensitizers for adjuvant therapy in combination with existing chemotherapy to increase the treatment efficacy.
References
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Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers
TL;DR: The study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects.
Journal ArticleDOI
High absorption but very low bioavailability of oral resveratrol in humans
TL;DR: The dietary polyphenol resveratrol has been shown to have chemopreventive activity against cardiovascular disease and a variety of cancers in model systems, but it is not clear whether the drug reaches the proposed sites of action in vivo after oral ingestion, especially in humans.
Journal ArticleDOI
PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel
TL;DR: The PKSolver provided pharmacokinetic researchers with a fast and easy-to-use tool for routine and basic PK and PD data analysis with a more user-friendly interface and its output could be generated in Microsoft Word in the form of an integrated report.