Journal ArticleDOI
PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel
TLDR
The PKSolver provided pharmacokinetic researchers with a fast and easy-to-use tool for routine and basic PK and PD data analysis with a more user-friendly interface and its output could be generated in Microsoft Word in the form of an integrated report.About:
This article is published in Computer Methods and Programs in Biomedicine.The article was published on 2010-09-01. It has received 1493 citations till now. The article focuses on the topics: Visual Basic for Applications.read more
Citations
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Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
Linlin Zhang,Daizong Lin,Xinyuanyuan Sun,Ute Curth,Christian Drosten,Lucie Sauerhering,Stephan Becker,Katharina Rox,Rolf Hilgenfeld +8 more
TL;DR: The pharmacokinetic characterization of the optimized inhibitor reveals a pronounced lung tropism and suitability for administration by the inhalative route and work that may provide a basis for development of anticoronaviral drugs.
Journal ArticleDOI
Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy.
Jundong Shao,Hanhan Xie,Hao Huang,Zhibin Li,Zhengbo Sun,Yanhua Xu,Quanlan Xiao,Xue-Feng Yu,Yuetao Zhao,Han Zhang,Huaiyu Wang,Paul K. Chu +11 more
TL;DR: In vitro and in vivo experiments demonstrate that the BPQDs/PLGA nanospheres have inappreciable toxicity and good biocompatibility, and possess excellent PTT efficiency and tumour targeting ability as evidenced by highly efficient tumour ablation under near infrared (NIR) laser illumination.
Journal ArticleDOI
Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a 13C-tracer study
C. Czank,Aedin Cassidy,Qingzhi Zhang,Douglas J. Morrison,Tom Preston,Paul A. Kroon,Nigel P. Botting,Colin D. Kay +7 more
TL;DR: Anthocyanins are more bioavailable than previously perceived, and their metabolites are present in the circulation for ≤48 h after ingestion, as investigated in humans.
Journal ArticleDOI
The pharmacokinetics of anthocyanins and their metabolites in humans
R. de Ferrars,C. Czank,Qingzhi Zhang,Nigel P. Botting,Paul A. Kroon,Aedin Cassidy,Colin D. Kay +6 more
TL;DR: The aim of the present study was to establish the pharmacokinetics of the metabolites of cyanidin‐3‐glucoside (C3G), a widely consumed dietary phytochemical with potential cardioprotective properties.
Journal ArticleDOI
Enhancing the bioavailability of resveratrol by combining it with piperine.
Jeremy J. Johnson,Minakshi Nihal,Imtiaz A. Siddiqui,Cameron O. Scarlett,Howard H. Bailey,Hasan Mukhtar,Nihal Ahmad +6 more
TL;DR: Piperine significantly improves the in vivo bioavailability of resveratrol through inhibiting its glucuronidation, thereby slowing its elimination and further detailed research is needed to study the mechanism of improved bioavailability via its combination with piperine.
References
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Book
Pharmacokinetic/pharmacodynamic data analysis : concepts and applications
Johan Gabrielsson,Daniel Weiner +1 more
TL;DR: This revised and expanded edition includes a CD with all exercises and WinNonlin model/ command files and raises the stature of PK/PD modeling to its highest level.
Journal ArticleDOI
A step-by-step guide to non-linear regression analysis of experimental data using a Microsoft Excel spreadsheet
TL;DR: The intent of this paper is to lead the reader through an easily understood step-by-step guide to implementing this method, which can be applied to any function in the form y=f(x), and is well suited to fast, reliable analysis of data in all fields of biology.
Journal ArticleDOI
Comparison of the Akaike Information Criterion, the Schwarz criterion and the F test as guides to model selection
TL;DR: Results indicate that theF test tends to choose the simpler model more often than does either the Akaike Information Criterion or the Schwarz Criterion, even when the more complex model is correct.
Journal ArticleDOI
Nonlinear regression using spreadsheets
W.P. Bowen,J.C. Jerman +1 more
TL;DR: A generic method of performing nonlinear regression using spreadsheet applications is described and how this approach can be used to create automated systems of data analysis is demonstrated.
Journal Article
Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications
TL;DR: This book emphasizes how to critically evaluate the output from fitting a model to data to applying statistical techniques for model selection and discussion, and provides unique insight into the field of pharmacometrics in a manner that is easy to understand.