Journal ArticleDOI
Enzymatic resolution of methyl 2-alkyl-2-arylacetates
TLDR
Horse liver esterase, used as its inexpensive commercial acetone powder, catalyzes the selective hydrolysis of methyl 2-alkyl-2-arylacetates to afford R(−)-2 -alkyl 2 -acetyl 2-arylacetic acids and S(+)-methyl 2 −alkyl -2-acetylacetates.About:
This article is published in Tetrahedron Letters.The article was published on 1989-01-01. It has received 45 citations till now. The article focuses on the topics: Esterase & Acetone.read more
Citations
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Journal ArticleDOI
Enzymes in the synthesis of chiral drugs.
TL;DR: The use of enzymes in the synthesis and modification of optically pure drugs is reviewed, with special attention on the synthesis of new pharmaceuticals which may require efficient procedures for large-scale synthesis in the future.
Journal ArticleDOI
Recent developments in the synthesis of optically active α-arylpropanoic acids: An important class of non-steroidal anti-inflammatory agents☆
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Application of biocatalysis and biotransformations to the synthesis of pharmaceuticals
Aleksey Zaks,David R. Dodds +1 more
TL;DR: This review covers examples of isolated enzymes and microorganisms used as catalysts for the synthesis of pharmacologically valuable materials, on both a laboratory and a commercial scale.
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Purification and properties of a novel arylmalonate decarboxylase from Alcaligenes bronchisepticus KU 1201.
Kenji Miyamoto,Hiromichi Ohta +1 more
TL;DR: A novel decarboxylase which catalyzes an enantioselective decar boxylation of alpha-aryl-alpha-methylmalonates to alpha- Darylpropionates has been purified from a soil bacterium Alcaligenes bronchisepticus KU 1201 and tentatively named as arylmalonate decarBoxylase.
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Resolution of rac-ketoprofen esters by enzymatic reactions in organic media
TL;DR: In this paper, the authors studied enzyme-catalyzed reactions in organic media of rac-ketoprofen esters with different nucleophiles such as alcohols, amines, and water.
References
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Asymmetric hydroformylation catalyzed by homogeneous and polymer-supported platinum complexes containing chiral phosphine ligands
TL;DR: In this paper, the authors proposed a method for the hydroformylation of styrene, isobutyl-4styrene, vinyl-2 et methoxy-6 vinyl 2 naphtalenes, acetate de vinyle, methacrylate de methyle, norbornene, en presence de chlorure stanneux et en presence d'orthoformiate de triethyle
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Tetrahedron report number 205
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Nonsteroidal antiinflammatory agents. I. 6-substituted 2-naphthylacetic acids
Ian T. Harrison,Brian. Lewis,Peter H. Nelson,Wendell H. Rooks,A. P. Roszkowski,Albert J. Tomolonis,John H Fried +6 more
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A facile enzymatic resolution process for the preparation of (+)-S-2-(6-methoxy-2-naphthyl)propionic acid (naproxen)
TL;DR: In this paper, an enantlospecific hydrolysis of (±)-chloroethyl-2-(6methoxy-2-naphthyl) propionate was performed by the lipase of Candida cylindracea.
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Stereoselective inversion of (R)‐fenoprofen to (S)‐fenoprofen in humans
TL;DR: A potency comparison of the enantiomers in vitro showed the (S)-isomer to be 35 times more active than the (R)-isomers in inhibiting the fatty acid cyclo-oxygenase pathway from human platelets.