Book ChapterDOI
Epidemiology of melanoma and nonmelanoma skin cancer--the role of sunlight.
Ulrike Leiter,Claus Garbe +1 more
TLDR
A dose-dependent increase in the risk of squamous cell carcinoma (SCC) of the skin was found associated with exposure to Psoralen and UVA irradiation as mentioned in this paper.Abstract:
Melanoma and nonmelanoma skin cancer (NMSC) are now the most common types of cancer in white populations. Both tumor entities show an increasing incidence rate worldwide but a stable or decreasing mortality rate.1,2 The rising incidence rates of NMSC are probably caused by a combination of increased sun exposure or exposure to ultraviolet (UV) light, increased outdoor activities, changes in clothing style, increased longevity, ozone depletion, genetics and in some cases, immune suppression. A dose-dependent increase in the risk of squamous cell carcinoma (SCC) of the skin was found associated with exposure to Psoralen and UVA irradiation. An intensive UV exposure in childhood and adolescence was causative for the development of basal cell carcinoma (BCC) whereas for the aetiology of SCC a chronic UV exposure in the earlier decades was accused.read more
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Journal ArticleDOI
A comprehensive catalogue of somatic mutations from a human cancer genome
Erin Pleasance,R. Keira Cheetham,Philip J. Stephens,David J. McBride,Sean Humphray,Christopher Greenman,Ignacio Varela,Meng-Lay Lin,Gonzalo R. Ordóñez,Graham R. Bignell,Kai Ye,Julie Alipaz,Markus J. Bauer,David Beare,Adam Butler,Richard J. Carter,Lina Chen,Anthony J. Cox,Sarah Edkins,Paula Kokko-Gonzales,Niall Anthony Gormley,Russell J. Grocock,Christian D. Haudenschild,Matthew M. Hims,Terena James,Mingming Jia,Zoya Kingsbury,Catherine Leroy,John Marshall,Andrew Menzies,Laura Mudie,Zemin Ning,Thomas Royce,Ole Schulz-Trieglaff,Anastassia Spiridou,Lucy Stebbings,Lukasz Szajkowski,Jon W. Teague,David Williamson,Lynda Chin,Mark T. Ross,Peter J. Campbell,David R. Bentley,P. Andrew Futreal,Michael R. Stratton,Michael R. Stratton +45 more
TL;DR: The genomes of a malignant melanoma and a lymphoblastoid cell line from the same person are sequenced, providing the first comprehensive catalogue of somatic mutations from an individual cancer.
Journal ArticleDOI
UV Radiation and the Skin
TL;DR: Developing UV-protective approaches based on a detailed understanding of molecular events that occur after UV exposure, focusing particularly on epidermal melanization and the role of the MC1R in genome maintenance are targeted.
Journal ArticleDOI
Vitamin D and Multiple Sclerosis
TL;DR: The results of these studies support a protective effect of vitamin D, but there are uncertainties and many unanswered questions, including how vitamin D exerts a Protective effect, how genetic variations modify the effect, and whether vitamin D can influence the course of MS progression.
Journal ArticleDOI
Signaling Pathways in Melanogenesis
TL;DR: The regulatory mechanisms involved in melanogenesis are discussed and how intrinsic and extrinsic factors regulate melanin production are explained, as well as the regulatory roles of different proteins involved in pigment molecules that are endogenously synthesized by melanocytes.
Journal ArticleDOI
Diagnosis and treatment of melanoma. European consensus-based interdisciplinary guideline – Update 2012
Claus Garbe,Ketty Peris,Axel Hauschild,Philippe Saiag,Mark R. Middleton,Alan Spatz,Jean-Jacques Grob,Josep Malvehy,Julia Newton-Bishop,Alexander J. Stratigos,Hubert Pehamberger,Alexander M.M. Eggermont +11 more
TL;DR: Therapeutic decisions in stage IV patients should be primarily made by an interdisciplinary oncology team ('Tumour Board'), based on systematic literature reviews and experts' experience.
References
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Journal ArticleDOI
Estimates of the worldwide incidence of 25 major cancers in 1990
TL;DR: There are large differences in the relative frequency of different cancers by world area, and tobacco smoking and chewing are almost certainly the major preventable causes of cancer today.
Journal ArticleDOI
The epidemiology of skin cancer.
Thomas L. Diepgen,V Mahler +1 more
TL;DR: Melanoma and non‐melanoma (basal and squamous cell carcinoma) skin cancer (NMSC) are now the most common types of cancer in the white populations and the incidence of skin cancer has reached epidemic proportions.
Journal ArticleDOI
The epidemiology of UV induced skin cancer.
Bruce K. Armstrong,Anne Kricker +1 more
TL;DR: The epidemiological data suggest that in implementing sun protection an increase in intermittency of exposure should be avoided, that sun protection will have the greatest impact if achieved as early as possible in life and that it will probably have an impact later in life, especially in those who had high childhood exposure to solar radiation.
Journal ArticleDOI
High frequency of BRAF mutations in nevi.
Pamela M. Pollock,Ursula Harper,Katherine S. Hansen,Laura M. Yudt,Mitchell S. Stark,Christiane M. Robbins,Tracy Moses,Galen Hostetter,Urs Wagner,John W. Kakareka,Ghadi Salem,Tom Pohida,Peter J. Heenan,Paul H. Duray,Olli Kallioniemi,Nicholas K. Hayward,Jeffrey M. Trent,Paul S. Meltzer +17 more
TL;DR: In this article, the authors evaluated the timing of mutations in BRAF during melanocytic neoplasia and found that mutations resulted in the V599E amino acid substitution in 41 of 60 (68%) melanoma metastases, 4 of 5 (80%) primary melanomas and, unexpectedly, in 63 of 77 (82%) nevi.
Journal ArticleDOI
Squamous cell carcinoma.
TL;DR: Papillomaviruses of both dogs and cats can predispose an animal to squamous cell carcinoma, and these tumors are most frequently diagnosed in animals that have sun-damaged skin.