Journal ArticleDOI
Epigenetic regulation of translation reveals hidden genetic variation to produce complex traits
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TLDR
[PSI+] expands the conceptual framework for phenotypic plasticity, provides a one-step mechanism for the acquisition of complex traits and affords a route to the genetic assimilation of initially transient epigenetic traits.Citations
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Protein Misfolding, Functional Amyloid, and Human Disease
TL;DR: The relative importance of the common main-chain and side-chain interactions in determining the propensities of proteins to aggregate is discussed and some of the evidence that the oligomeric fibril precursors are the primary origins of pathological behavior is described.
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Adaptive versus non‐adaptive phenotypic plasticity and the potential for contemporary adaptation in new environments
TL;DR: It is concluded that adaptive plasticity that places populations close enough to a new phenotypic optimum for directional selection to act is the only Plasticity that predictably enhances fitness and is most likely to facilitate adaptive evolution on ecological time-scales in new environments.
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Transgenerational epigenetic inheritance: prevalence, mechanisms, and implications for the study of heredity and evolution
Eva Jablonka,Gal Raz +1 more
TL;DR: The analysis of data shows that epigenetic inheritance is ubiquitous and suggests lines of research that go beyond present approaches to the subject, as well as pointing to the importance of recognizing and understanding epigenetics for practical and theoretical issues in biology.
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Functional amyloid--from bacteria to humans.
TL;DR: A greater understanding of the diverse physiological applications of this fold has the potential to provide a fresh perspective for the treatment of amyloid diseases.
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A systematic survey identifies prions and illuminates sequence features of prionogenic proteins
Simon Alberti,Randal Halfmann,Oliver D. King,Oliver D. King,Atul Kapila,Susan Lindquist,Susan Lindquist +6 more
TL;DR: A bioinformatic proteome-wide survey for prionogenic proteins in S. cerevisiae found an unexpected amino acid bias in aggregation-prone candidates and discovered that 19 of these could also form prions.
References
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Journal ArticleDOI
The diversity–stability debate
TL;DR: This issue — commonly referred to as the diversity–stability debate — is the subject of this review, which synthesizes historical ideas with recent advances and concludes that declines in diversity should be expected to accelerate the simplification of ecological communities.
Journal ArticleDOI
Guide to yeast genetics and molecular biology
Christine Guthrie,Gerald R. Fink +1 more
TL;DR: This volume and its companion, Volume 350, are specifically designed to meet the needs of graduate students and postdoctoral students as well as researchers, by providing all the up-to-date methods necessary to study genes in yeast.
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Hsp90 as a capacitor for morphological evolution
TL;DR: It is reported that when Drosophila Hsp90 is mutant or pharmacologically impaired, phenotypic variation affecting nearly any adult structure is produced, with specific variants depending on the genetic background and occurring both in laboratory strains and in wild populations.
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Phenotypic plasticity in the interactions and evolution of species.
TL;DR: Phenotypic responses in species interactions represent modifications that can lead to reciprocal change in ecological time, altered community patterns, and expanded evolutionary potential of species.
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The Effects of Plant Composition and Diversity on Ecosystem Processes
TL;DR: It is possible to identify and differentiate among potential mechanisms underlying patterns of ecosystem response to variation in plant diversity, with implications for resource management.
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A yeast prion provides a mechanism for genetic variation and phenotypic diversity
Heather L. True,Susan Lindquist +1 more