Book ChapterDOI
Epigenetic Targeting of Vascular Endothelial Growth Factor (VEGF) Receptors
Steven G. Gray
- pp 211-231
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The article was published on 2019-01-01. It has received 2 citations till now. The article focuses on the topics: Vascular endothelial growth factor B & Vascular endothelial growth factor C.read more
Citations
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The role of epigenetics in resistance to cisplatin chemotherapy in lung cancer
TL;DR: In this paper, the emerging evidence that epigenetics and the cellular machinery involved with this type of regulation may be key elements in the development of cisplatin resistance in NSCLC.
IL-20 is epigenetically regulated in NSCLC and down regulates the expression of VEGF
TL;DR: In this article, the expression of IL-20 and its cognate receptors (IL-20RA/B and IL-22R1) was examined in a series of resected fresh frozen NSCLC tumours.
References
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Journal ArticleDOI
The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data
Ethan Cerami,Jianjiong Gao,Ugur Dogrusoz,Benjamin Gross,Selcuk Onur Sumer,Bulent Arman Aksoy,Anders Jacobsen,Caitlin Byrne,Michael Heuer,Erik G. Larsson,Yevgeniy Antipin,Boris Reva,Arthur P. Goldberg,Chris Sander,Nikolaus Schultz +14 more
TL;DR: The cBio Cancer Genomics Portal significantly lowers the barriers between complex genomic data and cancer researchers who want rapid, intuitive, and high-quality access to molecular profiles and clinical attributes from large-scale cancer genomics projects and empowers researchers to translate these rich data sets into biologic insights and clinical applications.
Journal ArticleDOI
Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer
TL;DR: An integrated database and an online tool capable of uni- and multivariate analysis for in silico validation of new biomarker candidates in non-small cell lung cancer are established.
Journal ArticleDOI
Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses
Katherine B. Chiappinelli,Pamela L. Strissel,Alexis Desrichard,Huili Li,Christine Henke,Benjamin Akman,Alexander Hein,Neal S. Rote,Leslie Cope,Alexandra Snyder,Vladimir Makarov,Sadna Budhu,Dennis J. Slamon,Jedd D. Wolchok,Drew M. Pardoll,Matthias W. Beckmann,Cynthia A. Zahnow,Taha Merghoub,Timothy A. Chan,Stephen B. Baylin,Reiner Strick +20 more
TL;DR: In melanoma patients treated with an immune checkpoint therapy, high viral defense signature expression in tumors significantly associates with durable clinical response and DNMTi treatment sensitizes to anti-CTLA4 therapy in a pre-clinical melanoma model.
Journal Article
Tea Polyphenol (−)-Epigallocatechin-3-Gallate Inhibits DNA Methyltransferase and Reactivates Methylation-Silenced Genes in Cancer Cell Lines
TL;DR: It is reported herein that (-)-epigallocatechin-3-gallate (EGCG), the major polyphenol from green tea, can inhibit DNMT activity and reactivate methylation-silenced genes in cancer cells and the potential use of EGCG for the prevention or reversal of related gene-silencing in the prevention of carcinogenesis is suggested.
Journal ArticleDOI
VEGF targets the tumour cell
Hira Lal Goel,Arthur M. Mercurio +1 more
TL;DR: The function of vascular endothelial growth factor in cancer is not limited to angiogenesis and vascular permeability, and the neuropilins are crucial for mediating the effects of VEGF on tumour cells, primarily because of their ability to regulate the function and the trafficking of growth factor receptors and integrins.