Journal ArticleDOI
Esterase Activities in the Blood, Liver and Intestine of Several Preclinical Species and Humans
TLDR
Substantial species differences in activity of these esterases were observed between the mouse, rat, dog monkey and human, and such species differences must be considered when using these preclinical species to optimize the pharmacokinetic properties of ester compounds intended for human use.Abstract:
Species and tissue differences in the activity of three major classes of esterases, carboxylesterase (CE), butyrylcholinesterase (BChE) and paraoxonase (PON), were studied. Substantial species differences in activity of these esterases were observed between the mouse, rat, dog monkey and human. Such species differences must be considered when using these preclinical species to optimize the pharmacokinetic properties of ester compounds intended for human use.read more
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Dissertation
Bioconversion of the prodrug olmesartan medoxomil via carboxymethylene- butenolidase and paraoxonase 1
智子 石塚,トモコ イシヅカ,Tomoko Ishizuka +2 more
Running Title: Species differences in aspirin hydrolysis in plasma
TL;DR: This paper presents a meta-modelling procedure for estimating the total number of words in the text of a word-for-word description of a language-based system.
Journal ArticleDOI
Mouse Pharmacokinetics and In Vitro Metabolism of SH-11037 and SH-11008, Synthetic Homoisoflavonoids for Retinal Neovascularization
TL;DR: SH-11037 and SH-11008 both appear to possess pharmacokinetic profiles suboptimal as a systemic agent and are suggested to possess a low potential for systemic toxicity suitable as a topical ocular therapeutic agent.
Journal ArticleDOI
Залежність адаптаційної здатності мітохондрій печінки від способу виділення клітин
TL;DR: In situ liver perfusion is better method to obtain stable and metabolically active hepatocytes in support respiratory processes at a high level then in vitro perfusion.