Journal ArticleDOI
Esterase Activities in the Blood, Liver and Intestine of Several Preclinical Species and Humans
TLDR
Substantial species differences in activity of these esterases were observed between the mouse, rat, dog monkey and human, and such species differences must be considered when using these preclinical species to optimize the pharmacokinetic properties of ester compounds intended for human use.Abstract:
Species and tissue differences in the activity of three major classes of esterases, carboxylesterase (CE), butyrylcholinesterase (BChE) and paraoxonase (PON), were studied. Substantial species differences in activity of these esterases were observed between the mouse, rat, dog monkey and human. Such species differences must be considered when using these preclinical species to optimize the pharmacokinetic properties of ester compounds intended for human use.read more
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Effective Application of Metabolite Profiling in Drug Design and Discovery
Matthew A. Cerny,Amit S. Kalgutkar,R. Scott Obach,Raman Sharma,Douglas K. Spracklin,Gregory S. Walker +5 more
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Investigation into drug release from colon-specific azoreductase-activated steroid prodrugs using in-vitro models.
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Journal ArticleDOI
Esterase phenotyping in human liver in vitro: specificity of carboxylesterase inhibitors
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Journal ArticleDOI
Characterization of metabolites of GLS4 in humans using ultrahigh‐performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry
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