Esthesioneuroblastoma, Neuroendocrine Carcinoma, and Sinonasal Undifferentiated Carcinoma: Differentiation in Diagnosis and Treatment
TLDR
There are significant differences in prognosis and treatment for esthesioneuroblastoma, neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma.Abstract:
Introduction Malignant sinonasal tumors comprise less than 1% of all neoplasms. A wide variety of tumors occurring primarily in this site can present with an undifferentiated or poorly differentiated morphology. Among them are esthesioneuroblastomas, sinonasal undifferentiated carcinomas, and neuroendocrine carcinomas. Objectives We will discuss diagnostic strategies, recent advances in immunohistochemistry and molecular diagnosis, and treatment strategies. Data Synthesis These lesions are diagnostically challenging, and up to 30% of sinonasal malignancies referred to the University of Texas MD Anderson Cancer Center are given a different diagnosis on review of pathology. Correct classification is vital, as these tumors are significantly different in biological behavior and response to treatment. The past decade has witnessed advances in diagnosis and therapeutic modalities leading to improvements in survival. However, the optimal treatment for esthesioneuroblastoma, sinonasal undifferentiated carcinoma, and neuroendocrine carcinoma remain debated. We discuss advances in immunohistochemistry and molecular diagnosis, diagnostic strategies, and treatment selection. Conclusions There are significant differences in prognosis and treatment for esthesioneuroblastoma, neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma. Recent advances have the potential to improve oncologic outcomes but further investigation in needed.read more
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David Capper,Nils W. Engel,Nils W. Engel,Damian Stichel,Matt Lechner,Stefanie Glöss,Simone Schmid,Christian Koelsche,Christian Koelsche,Daniel Schrimpf,Daniel Schrimpf,Judith Niesen,Annika K. Wefers,Annika K. Wefers,David T.W. Jones,Martin Sill,Oliver Weigert,Keith L. Ligon,Adriana Olar,Arend Koch,Martin Forster,Sebastian Moran,Oscar M. Tirado,Miguel Sáinz-Jaspeado,Jaume Mora,Manel Esteller,Manel Esteller,Javier Alonso,Xavier Garcia del Muro,Werner Paulus,Jörg Felsberg,Guido Reifenberger,Markus Glatzel,Stephan Frank,Camelia M. Monoranu,Valerie J. Lund,Andreas von Deimling,Andreas von Deimling,Stefan M. Pfister,Stefan M. Pfister,Rolf Buslei,Julika Ribbat-Idel,Sven Perner,Volker Gudziol,Matthias Meinhardt,Ulrich Schüller +45 more
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Journal Article
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