Ethynylestradiol-Induced Impairment of Bile Secretion in the Rat: Protective Effects of S-Adenosyl-L-Methionine and Its Implication in Estrogen Metabolism
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TLDR
Data indicate that in ethynylestradiol treated rats S-adenosyl-l-methionine can reverse both cholestasis and related abnormalities of biliary lipids and modify the pattern but not the total amount of bile excretion.About:
This article is published in Gastroenterology.The article was published on 1981-01-01 and is currently open access. It has received 93 citations till now. The article focuses on the topics: Cholestasis.read more
Citations
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Intrahepatic cholestasis of pregnancy
TL;DR: The epidemiology, clinical features, diagnosis, etiology and management of intrahepatic cholestasis of pregnancy are reviewed.
Journal ArticleDOI
S-adenosylmethionine synthesis: molecular mechanisms and clinical implications.
TL;DR: The liver-specific isoenzymes are inhibited in human liver cirrhosis, and this is the cause of the abnormal metabolism of methionine in these subjects.
Journal ArticleDOI
S-Adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial
José M. Mato,Javier Cámara,Javier Fernández de Paz,Llorenç Caballería,Susana Coll,Antonio Caballero,Luisa García-Buey,Joaquín Beltrán,Vicente Benita,Joan Caballería,Ricard Solà,Ricardo Moreno-Otero,Félix Barrao,Antonio Martín-Duce,Jose A Correa,Albert Parés,Elena Barrao,Inmaculada Garcı́a-Magaz,J. Puerta,Jorge Moreno,Gabrielle Boissard,Pablo Ortiz,Joan Rodés +22 more
TL;DR: It is indicated that long-term treatment with AdoMet may improve survival or delay liver transplantation in patients with alcoholic liver cirrhosis, especially in those with less advanced liver disease.
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Drug‐induced cholestasis
TL;DR: This review summarizes their variable clinical presentations, examines the role of transport proteins in hepatic drug clearance and toxicity, and addresses the increasing importance of genetic determinants, as well as practical aspects of diagnosis and management.
Journal ArticleDOI
Xenobiotic-induced hepatotoxicity: mechanisms of liver injury and methods of monitoring hepatic function
TL;DR: The mechanisms of xenobiotic-induced liver injury, various factors that can alter the risk and severity of injury, the clinical and laboratory manifestations of injury; and the methods used to detect the presence of injury and (or) functioning liver mass are discussed.
References
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Enzymatic O-methylation of epinephrine and other catechols.
Julius Axelrod,Robert Tomchick +1 more
TL;DR: The properties of an enzyme that transfers the methyl group of S-adenosylmethionine to the hydroxyl group in position 3 of epinephrine and other catechols are described.
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[Enzymatic determination of total cholesterol in serum (author's transl)]
P Röschlau,E Bernt,W Gruber +2 more
TL;DR: Eine einfache enzymatische Methode zur Bestimmung des Gesamt-Cholesterins im Serum wird beschrieben, which bei dieser Reaktion entstehende Wasserstoffperoxyd oxydiert bei Anwesenheit von Katalase Methanol zu Formaldchyd.
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Mass spectrometry in structural and stereochemical problems
Steen Hammerum,Carl Djerassi +1 more
TL;DR: The mass spectral fragmentation of a number of steroidal delta4-3-ketones has been examined and reactions associated with the alpha,beta-unsaturated ketonic function are not particularly significant; rather, abundant ions are formed by decomposition processes occurring in and around ring D.
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Effects of Oral Contraceptives on the Gallbladder Bile of Normal Women
TL;DR: Findings show that exogenous sex steroids in doses and formulations routinely prescribed induce important alterations in the composition of human gallbladder bile, and suggest a biochemical basis for the increase in gallbladders disease observed among women using oral contraceptives.
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Biliary excretion of bile acids and cholesterol in bile fistula rats; bile acids and steroids.
TL;DR: A constant excretion pattern consisting of 2 parts was observed, resulting in an increased formation of bile acids resulting in a 10-20 fold increased synthesis of biles acids in the intact animal.