Journal ArticleDOI
Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii
Lisa A. Shamon,John M. Pezzuto,J. M. Graves,Rajeshwari R. Mehta,Sirichai Wangcharoentrakul,Ranee Sangsuwan,Suttiporn Chaichana,Patoomratana Tuchinda,Per Cleason,Vichai Reutrakul +9 more
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TLDR
Tripterygium wilfordii Hook f. (Celastraceae) has been shown to demonstrate potent antileukemic activity in rodent models at remarkably low treatment doses.About:
This article is published in Cancer Letters.The article was published on 1997-01-15. It has received 167 citations till now. The article focuses on the topics: Triptolide & Tripterygium wilfordii.read more
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XPB, a subunit of TFIIH, is a target of the natural product triptolide
Denis V. Titov,Benjamin Gilman,Qing-Li He,Shridhar Bhat,Woon-Kai Low,Woon-Kai Low,Yongjun Dang,Michael B. Smeaton,Arnold L. Demain,Paul S. Miller,Jennifer F. Kugel,James A. Goodrich,Jun O. Liu +12 more
TL;DR: It is reported that triptolide covalently binds to human XPB, a subunit of the transcription factor TFIIH, and inhibits its DNA-dependent ATPase activity, which leads to the inhibition of RNA polymerase II-mediated transcription and likely nucleotide excision repair.
Journal ArticleDOI
Immunosuppressive and Anti-Inflammatory Mechanisms of Triptolide, the Principal Active Diterpenoid from the Chinese Medicinal Herb Tripterygium wilfordii Hook. f.
Daoming Qiu,Peter N. Kao +1 more
TL;DR: Characterisation of the terpenoids present in extracts of Tripterygium identified triptolide, a diterpenoid triepoxide, as responsible for most of the immunosuppressive, anti-inflammatory and antiproliferative effects observed in vitro.
Journal Article
Triptolide inhibits the growth and metastasis of solid tumors.
Shanmin Yang,Jinguo Chen,Zhen Guo,Xue-Ming Xu,Luping Wang,Xu-Fang Pei,Jing Yang,Charles B Underhill,Lurong Zhang +8 more
TL;DR: Results suggest that TPL has several attractive features as a new antitumor agent, including induced apoptosis and reduced the expression of several molecules that regulate the cell cycle in cultured tumor cells.
Journal ArticleDOI
Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F.
TL;DR: Current available data suggest that triptolide is a promising immunosuppressive and anti-inflammatory agent and should be explored further in autoimmune diseases and transplantation.
References
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Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals
TL;DR: There is a high correlation between carcinogenicity and mutagenicity: 90% (156/174) of carcinogens are mutagenic in the test and despite the severe limitations inherent in defining non-carcinogenicity, few "non-Carcinogens" show any degree of mutageniability.
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Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis
E. Pisha,Heebyung Chai,Ik-Soo Lee,T E Chagwedera,Norman R. Farnsworth,Geoffrey A. Cordell,Chris Beecher,Harry H. S. Fong,A. D. Kinghorn,David M. Brown,David M. Brown +10 more
TL;DR: As a result of bioassay–guided fractionation, betulinic acid, a pentacyclic triterpene, was identified as a melanoma–specific cytotoxic agent and antitumour activity was mediated by the induction of apoptosis.
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Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification.
Ding-Wu Shen,Antonio Tito Fojo,Janice E. Chin,Igor B. Roninson,Nancy D. Richert,Ira Pastan,Michael M. Gottesman +6 more
TL;DR: Results suggest that increased expression of mdr1 mRNA is a common mechanism for multidrug resistance in human cells and that Activation of the m dr1 gene by mutations or epigenetic changes may precede its amplification during the development of resistance.
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Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii.
Journal ArticleDOI
Cytotoxic and antimalarial bisbenzylisoquinoline alkaloids from Stephania erecta.
Kittisak Likhitwitayawuid,Cindy K. Angerhofer,Geoffrey A. Cordell,John M. Pezzuto,Nijsiri Ruangrungsi +4 more
TL;DR: (+)-2-N-Methyltelobine, a new alkaloid, together with twelve known bisbenzylisoquinolines, was isolated from the tubers of Stephania erecta and did not appear to be promising clinical candidates at the present time.