Journal ArticleDOI
Evidence for the in vivo formation of ascorbic acid 2-O-α-glucoside in guinea pigs and rats
N Muto,Y Ban,M Akiba,I Yamamoto +3 more
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TLDR
It is concluded that AA-2G is a possible metabolite produced by enzymatic alpha-glucosidation after a combined administration of AA and maltose to guinea pigs and rats.About:
This article is published in Biochemical Pharmacology.The article was published on 1991-07-15. It has received 22 citations till now. The article focuses on the topics: Ascorbic acid & Metabolite.read more
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Journal ArticleDOI
Plant L‐ascorbic acid: chemistry, function, metabolism, bioavailability and effects of processing
Mark W. Davey,M. Van Montagu,Dirk Inzé,Maite Sanmartín,Angelos K. Kanellis,Nicholas Smirnoff,I. J. J. Benzie,John (Sean) J. Strain,D. Favell,J. Fletcher +9 more
TL;DR: The role of L-AA in metabolism and the latest studies regarding its bio- synthesis, tissue compartmentalisation, turnover and catabolism are focused on, as well as the potential to improve the L- AA content of crops.
Journal ArticleDOI
Ascorbate Metabolism and Its Regulation in Animals
TL;DR: The authors deal with the synthesis and the breakdown of ascorbate as a part of the antioxidant and carbohydrate metabolism, and a complex metabolic regulation is supposed.
Journal ArticleDOI
Functions, applications and production of 2-O- d -glucopyranosyl- l -ascorbic acid
TL;DR: This mini-review introduces the types and properties of different VC glycosyl derivatives and discusses in-depth the current status and future prospects of AA-2G production by biotransformation.
Journal ArticleDOI
Comparison of ascorbic acid and ascorbic acid 2-O-α-glucoside on the cytotoxicity and bioavailability to low density cultures of fibroblasts
TL;DR: The results suggest that the abnormally accumulated ascorbic acid in the cells cultured at low density possibly amplifies the generation of oxygen radicals through the reduction of Fe3+ ions and subsequent oxidative reactions, leading to cell death.
Journal ArticleDOI
Vitamin C Activity of 2-O-.ALPHA.-D-Glucopyranosyl-L-Ascorbic Acid in Guinea Pigs.
TL;DR: Results showed that AA-2G has the same vitamin C activity as AsA on a molar basis for the orally supplemented guinea pigs.
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Journal ArticleDOI
Safety of High‐level Vitamin C Ingestion
TL;DR: The ingestion of large doses of ascorbic acid is contraindicated in cases of renal insufficiency, chronic hemodialysis patients, unusual forms of iron overload, and oxalate stoneformers.
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L-Ascorbic Acid α-Glucoside Formed by Regioselective Transglucosylation with Rat Intestinal and Rice Seed α-Glucosidases : Its Improved Stability and Structure Determination
TL;DR: The definite structure and chemical stability of a new glucoside of L-ascorbic acid (AA) which was enzymatically glucosylated with rat intestinal and rice seed alpha-glucosidases were reported.
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Formation of a stable l-ascorbic acid α-glucoside by mammalian α-glucosidase-catalyzed transglucosylation
TL;DR: It is concluded that mammalian α-glucosidase is able to form a very stable and nonreducing form of glucosylated AA through a specific transGLucosylation reaction distinct from that of microbial α- glucOSidase.
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Inhibitors of trimming: new tools in glycoprotein research
Ralph T. Schwarz,Roelf Datema +1 more
TL;DR: These compounds are inhibitors of the trimming of mannose or glucose residues from precursors of oligosaccharides and can be used to study the role of glycoprotein processing in several biological systems.
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Antiscorbutic Activity of L-ascorbic Acid 2-glucoside and Its Availability as a Vitamin C Supplement in Normal Rats and Guinea Pigs
TL;DR: The results indicate that AA-2G is a readily available source of vitamin C activity in vivo, and was found to exhibit obvious therapeutic effect in scorbutic guinea pigs by its repeated oral administrations.