Journal ArticleDOI
Evidence for the role of lysosomes in the formation of prostaglandins during carrageenin induced inflammation in the rat
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It is suggested thatospholipases are freed from the lysosomes of leucocytes overactive in the endocytosis of carrageenin, and that these attack cell membrane phospholipid to give arachidonic acid which is converted to prostaglandin by freely available tissue enzymes.About:
This article is published in Pharmacological Research Communications.The article was published on 1971-03-01. It has received 124 citations till now. The article focuses on the topics: Prostaglandin & Bleb (cell biology).read more
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Mediators of the inflammation induced in the rat paw by carrageenin.
Pearl Crunkhorn,S. C. R. Meacock +1 more
TL;DR: It was concluded that kinins and 5‐HT contributed significantly to oedema formation during this period, and mepyramine and methysergide, at the doses used in the carrageenin experiments, completely antagonized histamine and5‐HT, respectively, and did not affect the skin responses of bradykinin.
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Perspectives in nonsteroidal anti-inflammatory agents.
TL;DR: Competitive binding and antagonistic interactions between nonsteroidal drugs, particularly salicylate, were observed in vitro and in vivo.
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Effects of non-steroidal anti-inflammatory agents on human neutrophil functions in vitro and in vivo.
Howard B. Kaplan,Henry S. Edelson,Helen M. Korchak,William P. Given,Steven B. Abramson,Gerald Weissmann +5 more
TL;DR: The data suggest that, although non-steroidal anti-inflammatory agents may inhibit discrete neutrophil functions both in vitro and in vivo, their effects do not duplicate those of polyenoic inhibitors of arachidonate metabolism.
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An endoperoxide aggregator (Lass), formed in platelets in response to thrombotic stimuli: purification, identification and unique biological significance.
TL;DR: It is concluded that platelet biosynthesis of LASS and PGE 2 mediates (in part or in full) irreversible platelet aggregation and the release reaction induced by collagen, thrombin, arachidonate, epinephrine or ADP.
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Prostaglandins and the immune response.
TL;DR: No definitive evidence exists that compounds other than the classical Pgs are active in immune cell inhibition, but the recent indications that Pgs may mediate their effects through the cyclic endoperoxides and non-prostanoate metabolites may prove to be an important challenge to the many proposed roles of Pgs.
References
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Release of Additional Factors in Anaphylaxis and its Antagonism by Anti-inflammatory Drugs
Priscilla J. Piper,John R. Vane +1 more
TL;DR: Among the active substances released during anaphylaxis in guinea-pig lung is a hitherto unidentified substance which has a contracting effect on rabbit aorta.
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Prostaglandins released by the Spleen
TL;DR: Experiments with dogs have shown that both prostaglandin E2 and F2α are released when the spleen is contracted by nerve stimulation or by adrenaline.
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The enzymatic formation of prostaglandin E2 from arachidonic acid prostaglandins and related factors 32
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Digestive activity of lysosomes. I. The digestion of proteins by extracts of rat liver lysosomes.
Stanley Fowler,C. de Duve +1 more
TL;DR: The lysosomes were found to have the ability to dephosphorylate phosphatidic acid, α-glycerophosphate, and, although rather slowly, the phosphomonoesters of choline, ethanolamine, and serine, which are clear to accomplish the important digestive functions with which they are credited.