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Journal ArticleDOI

Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs

Charles A. Winter, +2 more
- 01 Dec 1962 - 
- Vol. 111, Iss: 3, pp 544-547
TLDR
The potency ratios obtained for aspirin, phenylbutazone and hydrocortisone are fairly close to the ratios of their respective daily doses in the treatment of rheumatic disease.
Abstract: 
SummaryA method is presented for measuring the edema induced by injection of 0.05 ml of 1% solution of carrageenin, an extract of Chondrus, into the plantar tissues of the hind paw of the rat. Peak...

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Journal ArticleDOI

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.

Kenneth M. Hargreaves, +4 more
- 01 Jan 1988 - 
TL;DR: Both the thermal method and the Randall‐Selitto mechanical method detected dose‐related hyperalgesia and its blockade by either morphine or indomethacin, but the Thermal method showed greater bioassay sensitivity and allowed for the measurement of other behavioral parameters in addition to the nociceptive threshold.
Journal Article

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.

Mark J F Brown, +4 more
- 30 Dec 1987 - 
Journal ArticleDOI

Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).

T. D. Penning, +22 more
- 25 Apr 1997 - 
TL;DR: 1i (4-[5-(4-methylphenyl)-3-(trifluoromethyl)- H-pyrazol-1-yl]benzenesulfonamide, SC-58635, celecoxib), which is currently in phase III clinical trials for the treatment of rheumatoid arthritis and osteoarthritis, is identified.
Journal ArticleDOI

Studies on the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine.

M. Di Rosa, +2 more
- 01 May 1971 - 
Journal ArticleDOI

Hoe 140 a new potent and long acting bradykinin-antagonist: in vivo studies

K. Wirth, +10 more
- 01 Mar 1991 - 
TL;DR: Hoe 140 has been shown to be a highly potent and long acting BK antagonist in vivo in different animal species and models and makes it appropriate to investigate further the physiological and pathophysiological role of BK.