Book ChapterDOI
Excipients That Facilitate Amorphous Drug Stabilization
Yangjie Wei,Bhaswati Dattachowdhury,Kiran K. Vangara,Niraja Kiritkumar Patel,Kenneth S. Alexander,Sai H.S. Boddu +5 more
- pp 463-495
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TLDR
In this article, the authors highlight the delivery issues pertaining to amorphous drugs with a special emphasis on the most commonly used excipients in stabilizing amorphus drug substances in formulations.Abstract:
The importance of the amorphous state in studying bioavailability of poorly water-soluble drugs cannot be over-emphasized. The higher free energy and therefore the apparent high solubility of the amorphous phase are some of the advantages for promoting the amorphous phase, as compared to its crystalline counterpart. It is well known that the amorphous phase is thermodynamically unstable. This might result in the conversion of the metastable form to its stable crystalline form during storage. This conversion might also lead to product failure during storage owing to the poor dissolution properties of the crystalline form. Excipients can play a key role in preventing such a transformation during storage as well as maximizing the therapeutic efficacy of the amorphous material. This book chapter intends to highlight the delivery issues pertaining to amorphous drugs with a special emphasis on the most commonly used excipients in stabilizing amorphous drug substances in formulations.read more
Citations
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Journal ArticleDOI
Application of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticles.
TL;DR: This review introduces the application of FNP to produce poorly water-soluble drug nanoparticles by controllable mixing devices, such as confined impinging jets mixer (CIJM), multi-inlet vortex mixer (MIVM) and many other microfluidic mixer systems.
Book ChapterDOI
Organic Glass Scintillators
TL;DR: Organic Glass Scintillators (OGSs) as discussed by the authors are a class of materials that exhibit noteworthy physical and scintillation characteristics. But they are not suitable for radiation detection applications.
References
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Journal ArticleDOI
Supercooled liquids and the glass transition
TL;DR: Current theoretical knowledge of the manner in which intermolecular forces give rise to complex behaviour in supercooled liquids and glasses is discussed.
Journal ArticleDOI
Pharmaceutical Applications of Solid Dispersion Systems
Win Loung Chiou,Sidney Riegelman +1 more
Journal ArticleDOI
Characteristics and Significance of the Amorphous State in Pharmaceutical Systems
Bruno C. Hancock,George Zografi +1 more
TL;DR: The amorphous state is critical in determining the solid-state physical and chemical properties of many pharmaceutical dosage forms and some of the most common methods that can be used to measure them are described.
Book
Physics of amorphous materials
TL;DR: In this paper, the glass transition theories for glass transition factors that determine the glass-transition temperature glass-forming systems and ease of glass formation are discussed. But they do not consider the effects of defects.
Journal ArticleDOI
Amorphous pharmaceutical solids: preparation, characterization and stabilization.
TL;DR: Current research in the stabilization of amorphous solids focuses on the stabilize of labile substances during processing and storage using additives, the prevention of crystallization of the excipients that must remainAmorphous for their intended functions, and the selection of appropriate storage conditions under which amorphously solids are stable.