Exposure to Drinking Water Trihalomethanes and Their Association with Low Birth Weight and Small for Gestational Age in Genetically Susceptible Women
Asta Danileviciute,Regina Grazuleviciene,Jone Vencloviene,Algimantas Paulauskas,Mark J. Nieuwenhuijsen +4 more
TLDR
It is suggested that THM internal dose may affect foetal growth and that maternal GSTM1 genotype modifies the THM exposure effects on LBW.Abstract:
Little is known about genetic susceptibility to individual trihalomethanes (THM) in relation to adverse pregnancy outcomes. We conducted a nested case-control study of 682 pregnant women in Kaunas (Lithuania) and, using individual information on drinking water, ingestion, showering and bathing, and uptake factors of THMs in blood, estimated an internal THM dose. We used logistic regression to evaluate the relationship between internal THM dose, birth outcomes and individual and joint (modifying) effects of metabolic gene polymorphisms. THM exposure during entire pregnancy and specific trimesters slightly increased low birth weight (LBW) risk. When considering both THM exposure and maternal genotypes, the largest associations were found for third trimester among total THM (TTHM) and chloroform-exposed women with the GSTM1–0 genotype (OR: 4.37; 95% CI: 1.36–14.08 and OR: 5.06; 95% CI: 1.50–17.05, respectively). A test of interaction between internal THM dose and GSTM1–0 genotype suggested a modifying effect of exposure to chloroform and bromodichloromethane on LBW risk. However, the effect on small for gestational age (SGA) was not statistically significant. These data suggest that THM internal dose may affect foetal growth and that maternal GSTM1 genotype modifies the THM exposure effects on LBW.read more
Citations
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Maternal cigarette smoking, metabolic gene polymorphism, and infant birth weight
Xiaobin Wang,Barry Zuckerman,Colleen Pearson,Gary Kaufman,Changzhong Chen,Guoying Wang,Tianhua Niu,Paul H. Wise,Howard Bauchner,Xiping Xu +9 more
TL;DR: Maternal genotypes for enzymes participating in metabolism of polycyclic aromatic hydrocarbons alter the association between cigarette smoking and birth weight, and this finding raises the question of whether metabolic genes interact with smoking.
Journal ArticleDOI
Birth Weight, Ethnicity, and Exposure to Trihalomethanes and Haloacetic Acids in Drinking Water during Pregnancy in the Born in Bradford Cohort.
Rachel B. Smith,Susan C. Edwards,Nicky Best,John Wright,Mark J. Nieuwenhuijsen,Mireille B. Toledano +5 more
TL;DR: The findings demonstrate associations between THM, but not HAA, exposure during pregnancy and reduced birth weight, but suggest this differs by ethnicity, and suggest that THMs are not acting as a proxy for HAAs, or vice-versa.
Journal ArticleDOI
Total organic halogen (TOX) in human urine: A halogen-specific method for human exposure studies
TL;DR: A new comprehensive bioanalytical method has been developed that can quantify mixtures of organic halogenated compounds, including DBPs, in human urine as total organic chlorine (TOCl), total organic bromine (TOBr), and total organic iodine (TOI).
Journal ArticleDOI
Association Between Trihalomethane Concentrations in Drinking Water and Adverse Pregnancy Outcome in Taiwan
Chun-Yuh Yang,Shang-Shyue Tsai +1 more
TL;DR: The study results provide no evidence of an increased risk of TLBW, SGA, and preterm delivery at the relatively low concentrations of TTHMs in Taiwan's drinking water.
Journal ArticleDOI
Drinking Water Disinfection By-products, Genetic Polymorphisms, and Birth Outcomes in a European Mother–child Cohort Study
Manolis Kogevinas,Mariona Bustamante,Esther Gracia-Lavedan,Ferran Ballester,Sylvaine Cordier,Nathalie Costet,Ana Espinosa,Regina Grazuleviciene,Asta Danileviciute,Jesús Ibarluzea,Maria Karadanelli,Stuart W. Krasner,Evridiki Patelarou,Euripides G. Stephanou,Adonina Tardón,Mireille B. Toledano,John Wright,Cristina M. Villanueva,Mark J. Nieuwenhuijsen +18 more
TL;DR: There was no association between birth outcomes and trihalomethane exposures during pregnancy in the total population or in potentially genetically susceptible subgroups in this large European study.
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Journal Article
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