Exposure to Drinking Water Trihalomethanes and Their Association with Low Birth Weight and Small for Gestational Age in Genetically Susceptible Women
Asta Danileviciute,Regina Grazuleviciene,Jone Vencloviene,Algimantas Paulauskas,Mark J. Nieuwenhuijsen +4 more
TLDR
It is suggested that THM internal dose may affect foetal growth and that maternal GSTM1 genotype modifies the THM exposure effects on LBW.Abstract:
Little is known about genetic susceptibility to individual trihalomethanes (THM) in relation to adverse pregnancy outcomes. We conducted a nested case-control study of 682 pregnant women in Kaunas (Lithuania) and, using individual information on drinking water, ingestion, showering and bathing, and uptake factors of THMs in blood, estimated an internal THM dose. We used logistic regression to evaluate the relationship between internal THM dose, birth outcomes and individual and joint (modifying) effects of metabolic gene polymorphisms. THM exposure during entire pregnancy and specific trimesters slightly increased low birth weight (LBW) risk. When considering both THM exposure and maternal genotypes, the largest associations were found for third trimester among total THM (TTHM) and chloroform-exposed women with the GSTM1–0 genotype (OR: 4.37; 95% CI: 1.36–14.08 and OR: 5.06; 95% CI: 1.50–17.05, respectively). A test of interaction between internal THM dose and GSTM1–0 genotype suggested a modifying effect of exposure to chloroform and bromodichloromethane on LBW risk. However, the effect on small for gestational age (SGA) was not statistically significant. These data suggest that THM internal dose may affect foetal growth and that maternal GSTM1 genotype modifies the THM exposure effects on LBW.read more
Citations
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The Impact of Dehydration in the Third Trimesters on Pregnancy Outcome-Infant Birth Weight and Length
TL;DR: In addition to nutrient intake and weight gain during pregnancy, pregnant mothers should also concern for their fluid intake in order to maintain their health condition and feotal growth - development.
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Method to assess component contribution to toxicity of complex mixtures: Assessment of puberty acquisition in rats exposed to disinfection byproducts.
Shahid Parvez,Glenn E. Rice,Linda K. Teuschler,Jane Ellen Simmons,Thomas F. Speth,Susan D. Richardson,Richard J. Miltner,E. Sidney Hunter,Jonathan G. Pressman,Lillian F. Strader,Gary R. Klinefelter,Jerome M. Goldman,Michael G. Narotsky +12 more
TL;DR: In this article, a method based on regression modeling was developed to determine the contribution of component chemicals to the toxicity of highly complex, environmentally realistic mixtures of disinfection byproducts (DBPs).
Dissertation
Effets sanitaires de l'exposition aux sous-produits de chloration de l'eau
TL;DR: In this article, deux etudes evaluant les effets sur la sante humaine de l’exposition aux sous-produits de chloration (SPCs), dans le domaine du cancer and de la reproduction.
Journal ArticleDOI
Occurrence of trihalomethane in relation to treatment technologies and water quality under tropical conditions
TL;DR: In this article, the distribution of most prevalent disinfection byproducts, trihalomethanes (THMs) in relation to treatment technology and common water quality parameters (turbidity, conductivity, color, pH, and residual chlorine) was examined for two water supply schemes (WSS) in Sri Lanka.
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Association between exposure to drinking water disinfection byproducts and adverse pregnancy outcomes in South Africa
TL;DR: The findings suggest that exposure to THMs is associated with certain negative pregnancy outcomes, and the levels of THMs in water should be routinely monitored.
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